RSPO3 (R-spondin 3)

2012-10-01  

Identity

HGNC
RSPO3
LOCATION
6q22.33
LOCUSID
84870
ALIAS
CRISTIN1,PWTSR,THSD2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 84870
MIM: 610574
HGNC: 20866
Ensembl: ENSG00000146374

Variants:

dbSNP: 84870
ClinVar: 84870
TCGA: ENSG00000146374
COSMIC: RSPO3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000146374ENST00000356698Q9BXY4
ENSG00000146374ENST00000368317Q9BXY4

Expression (GTEx)

0
10
20
30
40
50
60
70
80
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by WntREACTOMER-HSA-195721
TCF dependent signaling in response to WNTREACTOMER-HSA-201681
Regulation of FZD by ubiquitinationREACTOMER-HSA-4641263

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
371731902023Amniotic fluid stem cell attenuated necrotizing enterocolitis progression by promoting Rspo3/AMPKα axis.1
379328192023Upregulation of RSPO3 via targeted promoter DNA demethylation inhibits the progression of cholangiocarcinoma.0
371731902023Amniotic fluid stem cell attenuated necrotizing enterocolitis progression by promoting Rspo3/AMPKα axis.1
379328192023Upregulation of RSPO3 via targeted promoter DNA demethylation inhibits the progression of cholangiocarcinoma.0
359959792022RSPO3 is a novel contraction-inducible factor identified in an "in vitro exercise model" using primary human myotubes.2
361299152022Investigation of cell signalings and therapeutic targets in PTPRK-RSPO3 fusion-positive colorectal cancer.0
359959792022RSPO3 is a novel contraction-inducible factor identified in an "in vitro exercise model" using primary human myotubes.2
361299152022Investigation of cell signalings and therapeutic targets in PTPRK-RSPO3 fusion-positive colorectal cancer.0
333207372021R-Spondins 2 and 3 Are Overexpressed in a Subset of Human Colon and Breast Cancers.6
343897132021RSPO3 is important for trabecular bone and fracture risk in mice and humans.16
333207372021R-Spondins 2 and 3 Are Overexpressed in a Subset of Human Colon and Breast Cancers.6
343897132021RSPO3 is important for trabecular bone and fracture risk in mice and humans.16
318515272020R-spondin3 promotes the tumor growth of choriocarcinoma JEG-3 cells.7
319909022020Elevated levels of the secreted wingless agonist R-spondin 3 in preeclamptic pregnancies.1
321602392020Targeting the Wnt signaling pathway through R-spondin 3 identifies an anti-fibrosis treatment strategy for multiple organs.16

Citation

Dessen P

RSPO3 (R-spondin 3)

Atlas Genet Cytogenet Oncol Haematol. 2012-10-01

Online version: http://atlasgeneticsoncology.org/gene/52917/tumors-explorer/