NMRAL1 (NmrA like redox sensor 1)

2012-10-01 Affiliation

Identity

HGNC

NMRAL1

LOCATION

16p13.3

LOCUSID

57407

ALIAS

HSCARG,SDR48A1

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 57407
HGNC: 24987
Ensembl: ENSG00000153406

Variants:

dbSNP: 57407
ClinVar: 57407
TCGA: ENSG00000153406
COSMIC: NMRAL1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000153406	ENST00000283429	Q9HBL8
ENSG00000153406	ENST00000283429	A0A384P622
ENSG00000153406	ENST00000404295	Q9HBL8
ENSG00000153406	ENST00000404295	A0A384P622
ENSG00000153406	ENST00000571291	I3L2U0
ENSG00000153406	ENST00000571448	I3L543
ENSG00000153406	ENST00000572110	I3L3Z0
ENSG00000153406	ENST00000572232	I3L1Y8
ENSG00000153406	ENST00000573520	I3L1Q7
ENSG00000153406	ENST00000573571	I3L0Y6
ENSG00000153406	ENST00000574425	Q9HBL8
ENSG00000153406	ENST00000574425	A0A384P622
ENSG00000153406	ENST00000574733	Q9HBL8
ENSG00000153406	ENST00000574733	A0A384P622
ENSG00000153406	ENST00000576176	I3L3I6

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Metabolism	REACTOME	R-HSA-1430728
Metabolism of amino acids and derivatives	REACTOME	R-HSA-71291
Urea cycle	REACTOME	R-HSA-70635
Metabolism of polyamines	REACTOME	R-HSA-351202

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
35094059	2022	Functional variant rs2270363 on 16p13.3 confers schizophrenia risk by regulating NMRAL1.	3
35094059	2022	Functional variant rs2270363 on 16p13.3 confers schizophrenia risk by regulating NMRAL1.	3
31796584	2019	Cellular redox sensor HSCARG negatively regulates the translesion synthesis pathway and exacerbates mammary tumorigenesis.	4
31796584	2019	Cellular redox sensor HSCARG negatively regulates the translesion synthesis pathway and exacerbates mammary tumorigenesis.	4
26694452	2015	Glucose-6-Phosphate Dehydrogenase Enhances Antiviral Response through Downregulation of NADPH Sensor HSCARG and Upregulation of NF-κB Signaling.	24
26694452	2015	Glucose-6-Phosphate Dehydrogenase Enhances Antiviral Response through Downregulation of NADPH Sensor HSCARG and Upregulation of NF-κB Signaling.	24
24711370	2014	HSCARG, a novel regulator of H2A ubiquitination by downregulating PRC1 ubiquitin E3 ligase activity, is essential for cell proliferation.	17
24763515	2014	HSCARG negatively regulates the cellular antiviral RIG-I like receptor signaling pathway by inhibiting TRAF3 ubiquitination via recruiting OTUB1.	33
24832601	2014	HSCARG downregulates NF-κB signaling by interacting with USP7 and inhibiting NEMO ubiquitination.	19
24711370	2014	HSCARG, a novel regulator of H2A ubiquitination by downregulating PRC1 ubiquitin E3 ligase activity, is essential for cell proliferation.	17
24763515	2014	HSCARG negatively regulates the cellular antiviral RIG-I like receptor signaling pathway by inhibiting TRAF3 ubiquitination via recruiting OTUB1.	33
24832601	2014	HSCARG downregulates NF-κB signaling by interacting with USP7 and inhibiting NEMO ubiquitination.	19
23527155	2013	HSCARG inhibits NADPH oxidase activity through regulation of the expression of p47phox.	4
23527155	2013	HSCARG inhibits NADPH oxidase activity through regulation of the expression of p47phox.	4
22348310	2012	A CRM1-dependent nuclear export signal controls nucleocytoplasmic translocation of HSCARG, which regulates NF-κB activity.	9

Citation

Dessen P

NMRAL1 (NmrA like redox sensor 1)

Atlas Genet Cytogenet Oncol Haematol. 2012-10-01

Online version: http://atlasgeneticsoncology.org/gene/52920