Identity
HGNC
LOCATION
16p13.3
LOCUSID
ALIAS
HSCARG,SDR48A1
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 57407
HGNC: 24987
Ensembl: ENSG00000153406
Variants:
dbSNP: 57407
ClinVar: 57407
TCGA: ENSG00000153406
COSMIC: NMRAL1
RNA/Proteins
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Metabolism | REACTOME | R-HSA-1430728 |
| Metabolism of amino acids and derivatives | REACTOME | R-HSA-71291 |
| Urea cycle | REACTOME | R-HSA-70635 |
| Metabolism of polyamines | REACTOME | R-HSA-351202 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 35094059 | 2022 | Functional variant rs2270363 on 16p13.3 confers schizophrenia risk by regulating NMRAL1. | 3 |
| 35094059 | 2022 | Functional variant rs2270363 on 16p13.3 confers schizophrenia risk by regulating NMRAL1. | 3 |
| 31796584 | 2019 | Cellular redox sensor HSCARG negatively regulates the translesion synthesis pathway and exacerbates mammary tumorigenesis. | 4 |
| 31796584 | 2019 | Cellular redox sensor HSCARG negatively regulates the translesion synthesis pathway and exacerbates mammary tumorigenesis. | 4 |
| 26694452 | 2015 | Glucose-6-Phosphate Dehydrogenase Enhances Antiviral Response through Downregulation of NADPH Sensor HSCARG and Upregulation of NF-κB Signaling. | 24 |
| 26694452 | 2015 | Glucose-6-Phosphate Dehydrogenase Enhances Antiviral Response through Downregulation of NADPH Sensor HSCARG and Upregulation of NF-κB Signaling. | 24 |
| 24711370 | 2014 | HSCARG, a novel regulator of H2A ubiquitination by downregulating PRC1 ubiquitin E3 ligase activity, is essential for cell proliferation. | 17 |
| 24763515 | 2014 | HSCARG negatively regulates the cellular antiviral RIG-I like receptor signaling pathway by inhibiting TRAF3 ubiquitination via recruiting OTUB1. | 33 |
| 24832601 | 2014 | HSCARG downregulates NF-κB signaling by interacting with USP7 and inhibiting NEMO ubiquitination. | 19 |
| 24711370 | 2014 | HSCARG, a novel regulator of H2A ubiquitination by downregulating PRC1 ubiquitin E3 ligase activity, is essential for cell proliferation. | 17 |
| 24763515 | 2014 | HSCARG negatively regulates the cellular antiviral RIG-I like receptor signaling pathway by inhibiting TRAF3 ubiquitination via recruiting OTUB1. | 33 |
| 24832601 | 2014 | HSCARG downregulates NF-κB signaling by interacting with USP7 and inhibiting NEMO ubiquitination. | 19 |
| 23527155 | 2013 | HSCARG inhibits NADPH oxidase activity through regulation of the expression of p47phox. | 4 |
| 23527155 | 2013 | HSCARG inhibits NADPH oxidase activity through regulation of the expression of p47phox. | 4 |
| 22348310 | 2012 | A CRM1-dependent nuclear export signal controls nucleocytoplasmic translocation of HSCARG, which regulates NF-κB activity. | 9 |
Citation
Dessen P
NMRAL1 (NmrA like redox sensor 1)
Atlas Genet Cytogenet Oncol Haematol. 2012-10-01
Online version: http://atlasgeneticsoncology.org/gene/52920/nmral1
