HLX (H2.0 like homeobox)

2012-11-01  

Identity

HGNC
HLX
LOCATION
1q41
LOCUSID
3142
ALIAS
HB24,HLX1

Other Information

Locus ID:

NCBI: 3142
MIM: 142995
HGNC: 4978
Ensembl: ENSG00000136630

Variants:

dbSNP: 3142
ClinVar: 3142
TCGA: ENSG00000136630
COSMIC: HLX

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000136630ENST00000366903Q14774
ENSG00000136630ENST00000427693F8VWZ5

Expression (GTEx)

0
10
20
30
40
50
60
70
80
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
311415392019Epstein-Barr virus (EBV) activates NKL homeobox gene HLX in DLBCL.14
311415392019Epstein-Barr virus (EBV) activates NKL homeobox gene HLX in DLBCL.14
292125712018Expression of Homeobox Gene HLX and its Downstream Target Genes are Altered in Placentae From Discordant Twin Pregnancies.2
300828232018A metabolic interplay coordinated by HLX regulates myeloid differentiation and AML through partly overlapping pathways.11
292125712018Expression of Homeobox Gene HLX and its Downstream Target Genes are Altered in Placentae From Discordant Twin Pregnancies.2
300828232018A metabolic interplay coordinated by HLX regulates myeloid differentiation and AML through partly overlapping pathways.11
287016932017Transcription factor Hlx controls a systematic switch from white to brown fat through Prdm16-mediated co-activation.22
288985472017HLX is a candidate gene for a pattern of anomalies associated with congenital diaphragmatic hernia, short bowel, and asplenia.8
287016932017Transcription factor Hlx controls a systematic switch from white to brown fat through Prdm16-mediated co-activation.22
288985472017HLX is a candidate gene for a pattern of anomalies associated with congenital diaphragmatic hernia, short bowel, and asplenia.8
266310392016H2.0-like homeobox 1 acts as a tumor suppressor in hepatocellular carcinoma.6
273352612016Screening of Human cDNA Library Reveals Two differentiation-Related Genes, HHEX and HLX, as Promoters of Early Phase Reprogramming toward Pluripotency.7
266310392016H2.0-like homeobox 1 acts as a tumor suppressor in hepatocellular carcinoma.6
273352612016Screening of Human cDNA Library Reveals Two differentiation-Related Genes, HHEX and HLX, as Promoters of Early Phase Reprogramming toward Pluripotency.7
220142092012Functional polymorphisms in TBX21 and HLX are associated with development and prognosis of Graves' disease.6

Citation

Dessen P

HLX (H2.0 like homeobox)

Atlas Genet Cytogenet Oncol Haematol. 2012-11-01

Online version: http://atlasgeneticsoncology.org/gene/52930