CABIN1 (calcineurin binding protein 1)

2012-11-01  

Identity

HGNC
CABIN1
LOCATION
22q11.23
LOCUSID
23523
ALIAS
CAIN,KB-318B8.7,PPP3IN
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 23523
MIM: 604251
HGNC: 24187
Ensembl: ENSG00000099991

Variants:

dbSNP: 23523
ClinVar: 23523
TCGA: ENSG00000099991
COSMIC: CABIN1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000099991ENST00000263119Q9Y6J0
ENSG00000099991ENST00000263119A0A024R1E5
ENSG00000099991ENST00000337989B5MEB3
ENSG00000099991ENST00000398319Q9Y6J0
ENSG00000099991ENST00000398319A0A024R1E5
ENSG00000099991ENST00000405822Q9Y6J0
ENSG00000099991ENST00000445422C9J068
ENSG00000099991ENST00000454754C9JT60
ENSG00000099991ENST00000617531A0A087WWW8

Expression (GTEx)

0
10
20
30
40
50
60
70
80
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cellular responses to stressREACTOMER-HSA-2262752
Cellular SenescenceREACTOMER-HSA-2559583
DNA Damage/Telomere Stress Induced SenescenceREACTOMER-HSA-2559586
Formation of Senescence-Associated Heterochromatin Foci (SAHF)REACTOMER-HSA-2559584

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
300827902018Functional activity of the H3.3 histone chaperone complex HIRA requires trimerization of the HIRA subunit.25
300827902018Functional activity of the H3.3 histone chaperone complex HIRA requires trimerization of the HIRA subunit.25
239399522014EBV-encoded LMP-1 sensitizes nasopharyngeal carcinoma cells to genotoxic drugs by down-regulating Cabin1 expression.5
239399522014EBV-encoded LMP-1 sensitizes nasopharyngeal carcinoma cells to genotoxic drugs by down-regulating Cabin1 expression.5
236245252013Genome-wide association analyses in Han Chinese identify two new susceptibility loci for amyotrophic lateral sclerosis.28
236245252013Genome-wide association analyses in Han Chinese identify two new susceptibility loci for amyotrophic lateral sclerosis.28
222752662012Regulation of inflammatory responses and fibroblast-like synoviocyte apoptosis by calcineurin-binding protein 1 in mice with collagen-induced arthritis.10
224013102012Identification of an ubinuclein 1 region required for stability and function of the human HIRA/UBN1/CABIN1/ASF1a histone H3.3 chaperone complex.19
222752662012Regulation of inflammatory responses and fibroblast-like synoviocyte apoptosis by calcineurin-binding protein 1 in mice with collagen-induced arthritis.10
224013102012Identification of an ubinuclein 1 region required for stability and function of the human HIRA/UBN1/CABIN1/ASF1a histone H3.3 chaperone complex.19
218078932011Human CABIN1 is a functional member of the human HIRA/UBN1/ASF1a histone H3.3 chaperone complex.51
218078932011Human CABIN1 is a functional member of the human HIRA/UBN1/ASF1a histone H3.3 chaperone complex.51
200759442010A case-control association analysis of CABIN1 with schizophrenia in a Japanese population.0
200759442010A case-control association analysis of CABIN1 with schizophrenia in a Japanese population.0
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.78

Citation

Dessen P

CABIN1 (calcineurin binding protein 1)

Atlas Genet Cytogenet Oncol Haematol. 2012-11-01

Online version: http://atlasgeneticsoncology.org/gene/52975/case-report-explorer/favicon/js/web-card-_common.js