DEPDC1B (DEP domain containing 1B)

2012-11-01  

Identity

HGNC
LOCATION
5q12.1
LOCUSID
ALIAS
BRCC3,XTP1
FUSION GENES

Other Information

Locus ID:

NCBI: 55789
MIM: 616073
HGNC: 24902
Ensembl: ENSG00000035499

Variants:

dbSNP: 55789
ClinVar: 55789
TCGA: ENSG00000035499
COSMIC: DEPDC1B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000035499ENST00000265036Q8WUY9
ENSG00000035499ENST00000453022Q8WUY9
ENSG00000035499ENST00000512078D6RIB0
ENSG00000035499ENST00000512452D6RDV9

Expression (GTEx)

0
5
10
15
20
25
30

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
Rho GTPase cycleREACTOMER-HSA-194840

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
379793962024DEPDC1B enhances malignant phenotypes of multiple myeloma through upregulating CCNB1 and inhibiting p53 signaling pathway.0
386141252024ZNF146 regulates cell cycle progression via TFDP1 and DEPDC1B in ovarian cancer cells.0
389400352024DEPDC1B is a Novel Direct Target of B-Myb and Contributes to Malignant Progression and Immune Infiltration in Lung Adenocarcinoma.0
379793962024DEPDC1B enhances malignant phenotypes of multiple myeloma through upregulating CCNB1 and inhibiting p53 signaling pathway.0
386141252024ZNF146 regulates cell cycle progression via TFDP1 and DEPDC1B in ovarian cancer cells.0
389400352024DEPDC1B is a Novel Direct Target of B-Myb and Contributes to Malignant Progression and Immune Infiltration in Lung Adenocarcinoma.0
360165122023DEPDC1B promotes colorectal cancer via facilitating cell proliferation and migration while inhibiting apoptosis.3
369130762023Circ_0005276 Promotes Prostate Cancer Progression Through the Crosstalk of miR-128-3p/DEPDC1B Axis.0
372034032023DEPDC1B is involved in the proliferation, metastasis, cell cycle arrest and apoptosis of colon cancer cells by regulating NUP37.3
376422352023DEPDC1B-mediated USP5 deubiquitination of β-catenin promotes breast cancer metastasis by activating the wnt/β-catenin pathway.1
360165122023DEPDC1B promotes colorectal cancer via facilitating cell proliferation and migration while inhibiting apoptosis.3
369130762023Circ_0005276 Promotes Prostate Cancer Progression Through the Crosstalk of miR-128-3p/DEPDC1B Axis.0
372034032023DEPDC1B is involved in the proliferation, metastasis, cell cycle arrest and apoptosis of colon cancer cells by regulating NUP37.3
376422352023DEPDC1B-mediated USP5 deubiquitination of β-catenin promotes breast cancer metastasis by activating the wnt/β-catenin pathway.1
349833032022DEP domain containing 1B (DEPDC1B) exerts the tumor promoter in hepatocellular carcinoma through activating p53 signaling pathway via kinesin family member 23 (KIF23).2

Citation

Dessen P

DEPDC1B (DEP domain containing 1B)

Atlas Genet Cytogenet Oncol Haematol. 2012-11-01

Online version: http://atlasgeneticsoncology.org/gene/52992/haematological-explorer/js/css/lib/dataTables.bootstrap.min.css