EIF4E2 (eukaryotic translation initiation factor 4E family member 2)

2012-11-01  

Identity

HGNC
EIF4E2
LOCATION
2q37.1
LOCUSID
9470
ALIAS
4E-LP,4EHP,EIF4EL3,IF4e,h4EHP
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 9470
MIM: 605895
HGNC: 3293
Ensembl: ENSG00000135930

Variants:

dbSNP: 9470
ClinVar: 9470
TCGA: ENSG00000135930
COSMIC: EIF4E2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000135930ENST00000258416O60573
ENSG00000135930ENST00000258416Q53RG0
ENSG00000135930ENST00000409098O60573
ENSG00000135930ENST00000409167B4E1E4
ENSG00000135930ENST00000409322B8ZZL3
ENSG00000135930ENST00000409394B9A023
ENSG00000135930ENST00000409495B9A044
ENSG00000135930ENST00000409514B8ZZ50
ENSG00000135930ENST00000444113H7BZH2
ENSG00000135930ENST00000454501C9JEL3

Expression (GTEx)

0
5
10
15
20
25
30
35
40
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
mTOR signaling pathwayKEGGko04150
Insulin signaling pathwayKEGGko04910
mTOR signaling pathwayKEGGhsa04150
Insulin signaling pathwayKEGGhsa04910
RNA transportKEGGko03013
RNA transportKEGGhsa03013
eIF4F complexKEGGhsa_M00428
PI3K-Akt signaling pathwayKEGGhsa04151
PI3K-Akt signaling pathwayKEGGko04151
HIF-1 signaling pathwayKEGGhsa04066
eIF4F complexKEGGM00428
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Interferon SignalingREACTOMER-HSA-913531
Antiviral mechanism by IFN-stimulated genesREACTOMER-HSA-1169410
ISG15 antiviral mechanismREACTOMER-HSA-1169408
Longevity regulating pathwayKEGGhsa04211
EGFR tyrosine kinase inhibitor resistanceKEGGko01521
EGFR tyrosine kinase inhibitor resistanceKEGGhsa01521

References

Pubmed IDYearTitleCitations
368409452023METTL16 promotes translation and lung tumorigenesis by sequestering cytoplasmic eIF4E2.14
368409452023METTL16 promotes translation and lung tumorigenesis by sequestering cytoplasmic eIF4E2.14
335810762021microRNA-induced translational control of antiviral immunity by the cap-binding protein 4EHP.14
337853062021High EIF4E2 expression is an independent prognostic risk factor for poor overall survival and recurrence-free survival in uveal melanoma.3
346658232021Translational repression of NMD targets by GIGYF2 and EIF4E2.17
335810762021microRNA-induced translational control of antiviral immunity by the cap-binding protein 4EHP.14
337853062021High EIF4E2 expression is an independent prognostic risk factor for poor overall survival and recurrence-free survival in uveal melanoma.3
346658232021Translational repression of NMD targets by GIGYF2 and EIF4E2.17
327265782020GIGYF2 and 4EHP Inhibit Translation Initiation of Defective Messenger RNAs to Assist Ribosome-Associated Quality Control.81
3305335520204EHP and GIGYF1/2 Mediate Translation-Coupled Messenger RNA Decay.27
327265782020GIGYF2 and 4EHP Inhibit Translation Initiation of Defective Messenger RNAs to Assist Ribosome-Associated Quality Control.81
3305335520204EHP and GIGYF1/2 Mediate Translation-Coupled Messenger RNA Decay.27
289425922018Major splice variants and multiple polyadenylation site utilization in mRNAs encoding human translation initiation factors eIF4E1 and eIF4E3 regulate the translational regulators?4
289912292018Hypoxia activates cadherin-22 synthesis via eIF4E2 to drive cancer cell migration, invasion and adhesion.18
294121402018Translational control of ERK signaling through miRNA/4EHP-directed silencing.23

Citation

Dessen P

EIF4E2 (eukaryotic translation initiation factor 4E family member 2)

Atlas Genet Cytogenet Oncol Haematol. 2012-11-01

Online version: http://atlasgeneticsoncology.org/gene/52997/teaching-explorer/css/meetings/