KIF3B (kinesin family member 3B)

2012-11-01  

Identity

HGNC
KIF3B
LOCATION
20q11.21
LOCUSID
9371
ALIAS
FLA8,HH0048,KLP-11,RP89
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 9371
MIM: 603754
HGNC: 6320
Ensembl: ENSG00000101350

Variants:

dbSNP: 9371
ClinVar: 9371
TCGA: ENSG00000101350
COSMIC: KIF3B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000101350ENST00000375712O15066

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Organelle biogenesis and maintenanceREACTOMER-HSA-1852241
Cilium AssemblyREACTOMER-HSA-5617833
Intraflagellar transportREACTOMER-HSA-5620924
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
MHC class II antigen presentationREACTOMER-HSA-2132295
HemostasisREACTOMER-HSA-109582
Factors involved in megakaryocyte development and platelet productionREACTOMER-HSA-983231
KinesinsREACTOMER-HSA-983189
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Translocation of GLUT4 to the plasma membraneREACTOMER-HSA-1445148
Intra-Golgi and retrograde Golgi-to-ER trafficREACTOMER-HSA-6811442
Golgi-to-ER retrograde transportREACTOMER-HSA-8856688
COPI-dependent Golgi-to-ER retrograde trafficREACTOMER-HSA-6811434

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
349180362022KIF3B gene silent variant leading to sperm morphology and motility defects and male infertility†.3
349180362022KIF3B gene silent variant leading to sperm morphology and motility defects and male infertility†.3
317464862020Kinesin Kif3b mutation reduces NMDAR subunit NR2A trafficking and causes schizophrenia-like phenotypes in mice.28
322370342020Identification of kinesin family member 3B (KIF3B) as a molecular target for gastric cancer.4
323865582020Mutations in the Kinesin-2 Motor KIF3B Cause an Autosomal-Dominant Ciliopathy.19
331533902020Circular RNA circ_0032462 Enhances Osteosarcoma Cell Progression by Promoting KIF3B Expression.2
317464862020Kinesin Kif3b mutation reduces NMDAR subunit NR2A trafficking and causes schizophrenia-like phenotypes in mice.28
322370342020Identification of kinesin family member 3B (KIF3B) as a molecular target for gastric cancer.4
323865582020Mutations in the Kinesin-2 Motor KIF3B Cause an Autosomal-Dominant Ciliopathy.19
331533902020Circular RNA circ_0032462 Enhances Osteosarcoma Cell Progression by Promoting KIF3B Expression.2
307201712019MiR-127-3p targets KIF3B to inhibit the development of oral squamous cell carcinoma.12
311579872019KIF3B Promotes the Proliferation of Pancreatic Cancer.3
317736952019LEF-AS1 participates in occurrence of colorectal cancer through adsorbing miR-505 and promoting KIF3B expression.3
307201712019MiR-127-3p targets KIF3B to inhibit the development of oral squamous cell carcinoma.12
311579872019KIF3B Promotes the Proliferation of Pancreatic Cancer.3

Citation

Dessen P

KIF3B (kinesin family member 3B)

Atlas Genet Cytogenet Oncol Haematol. 2012-11-01

Online version: http://atlasgeneticsoncology.org/gene/53015