LRRFIP1 (LRR binding FLII interacting protein 1)

2012-11-01  

Identity

HGNC
LOCATION
2q37.3
LOCUSID
ALIAS
FLAP-1,FLAP1,FLIIAP1,GCF-2,GCF2,HUFI-1,TRIP
FUSION GENES

Other Information

Locus ID:

NCBI: 9208
MIM: 603256
HGNC: 6702
Ensembl: ENSG00000124831

Variants:

dbSNP: 9208
ClinVar: 9208
TCGA: ENSG00000124831
COSMIC: LRRFIP1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000124831ENST00000244815Q32MZ4
ENSG00000124831ENST00000289175Q32MZ4
ENSG00000124831ENST00000289175A0A0F7NGI8
ENSG00000124831ENST00000308482Q32MZ4
ENSG00000124831ENST00000392000Q32MZ4
ENSG00000124831ENST00000420665C9JTC6

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
DiseaseREACTOMER-HSA-1643685
Diseases of signal transductionREACTOMER-HSA-5663202
Signaling by FGFR in diseaseREACTOMER-HSA-1226099
Signaling by FGFR1 in diseaseREACTOMER-HSA-5655302
FGFR1 mutant receptor activationREACTOMER-HSA-1839124
Signaling by cytosolic FGFR1 fusion mutantsREACTOMER-HSA-1839117
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Cytosolic sensors of pathogen-associated DNAREACTOMER-HSA-1834949
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN productionREACTOMER-HSA-3134973

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
353385702022LRRFIP1, an epigenetically regulated gene, is a prognostic biomarker and predicts malignant phenotypes of glioma.1
353385702022LRRFIP1, an epigenetically regulated gene, is a prognostic biomarker and predicts malignant phenotypes of glioma.1
307090602019Multidisciplinary Roles of LRRFIP1/GCF2 in Human Biological Systems and Diseases.12
307090602019Multidisciplinary Roles of LRRFIP1/GCF2 in Human Biological Systems and Diseases.12
299965582018Recombinant Leucine-Rich Repeat Flightless-Interacting Protein-1 Improves Healing of Acute Wounds through Its Effects on Proliferation Inflammation and Collagen Deposition.6
299965582018Recombinant Leucine-Rich Repeat Flightless-Interacting Protein-1 Improves Healing of Acute Wounds through Its Effects on Proliferation Inflammation and Collagen Deposition.6
260475732015Silencing of LRRFIP1 reverses the epithelial-mesenchymal transition via inhibition of the Wnt/β-catenin signaling pathway.23
260475732015Silencing of LRRFIP1 reverses the epithelial-mesenchymal transition via inhibition of the Wnt/β-catenin signaling pathway.23
245675342014Noncoding RNAs and LRRFIP1 regulate TNF expression.12
246901742014Higher LRRFIP1 expression in glioblastoma multiforme is associated with better response to teniposide, a type II topoisomerase inhibitor.6
247618962014Knockdown of GCF2/LRRFIP1 by RNAi causes cell growth inhibition and increased apoptosis in human hepatoma HepG2 cells.7
245675342014Noncoding RNAs and LRRFIP1 regulate TNF expression.12
246901742014Higher LRRFIP1 expression in glioblastoma multiforme is associated with better response to teniposide, a type II topoisomerase inhibitor.6
247618962014Knockdown of GCF2/LRRFIP1 by RNAi causes cell growth inhibition and increased apoptosis in human hepatoma HepG2 cells.7
230990212013Crystal structure of the dimeric coiled-coil domain of the cytosolic nucleic acid sensor LRRFIP1.7

Citation

Dessen P

LRRFIP1 (LRR binding FLII interacting protein 1)

Atlas Genet Cytogenet Oncol Haematol. 2012-11-01

Online version: http://atlasgeneticsoncology.org/gene/53021/lrrfip1