NOP2 (NOP2 nucleolar protein)

2012-11-01  

Identity

HGNC
NOP2
LOCATION
12p13.31
LOCUSID
4839
ALIAS
NOL1,NOP120,NSUN1,p120
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 4839
MIM: 164031
HGNC: 7867
Ensembl: ENSG00000111641

Variants:

dbSNP: 4839
ClinVar: 4839
TCGA: ENSG00000111641
COSMIC: NOP2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000111641ENST00000322166P46087
ENSG00000111641ENST00000382421P46087
ENSG00000111641ENST00000399466P46087
ENSG00000111641ENST00000536124F5H709
ENSG00000111641ENST00000537442P46087
ENSG00000111641ENST00000538420F5H8G6
ENSG00000111641ENST00000540228F5H359
ENSG00000111641ENST00000541778P46087
ENSG00000111641ENST00000542867F5H5X6
ENSG00000111641ENST00000542944F5GYR3
ENSG00000111641ENST00000545200P46087
ENSG00000111641ENST00000545492F5GWB7
ENSG00000111641ENST00000545915F5H359
ENSG00000111641ENST00000617555P46087
ENSG00000111641ENST00000620535P46087

Expression (GTEx)

0
10
20
30
40
50
60
70
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
rRNA processingREACTOMER-HSA-72312
rRNA modification in the nucleus and cytosolREACTOMER-HSA-6790901
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factorsREACTOMER-HSA-8864260
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiationREACTOMER-HSA-8869496
rRNA processing in the nucleus and cytosolREACTOMER-HSA-8868773

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
374980632023NOP2-mediated m5C methylation of XPD is associated with hepatocellular carcinoma progression.8
374980632023NOP2-mediated m5C methylation of XPD is associated with hepatocellular carcinoma progression.8
353818322022Upregulated expression of NOP2 predicts worse prognosis of gastric adenocarcinoma by promoting tumor growth.4
361614842022Human NOP2/NSUN1 regulates ribosome biogenesis through non-catalytic complex formation with box C/D snoRNPs.21
353818322022Upregulated expression of NOP2 predicts worse prognosis of gastric adenocarcinoma by promoting tumor growth.4
361614842022Human NOP2/NSUN1 regulates ribosome biogenesis through non-catalytic complex formation with box C/D snoRNPs.21
321767342020Nucleolar protein NOP2/NSUN1 suppresses HIV-1 transcription and promotes viral latency by competing with Tat for TAR binding and methylation.38
325548582020Long noncoding RNA LINC00963 induces NOP2 expression by sponging tumor suppressor miR-542-3p to promote metastasis in prostate cancer.20
321767342020Nucleolar protein NOP2/NSUN1 suppresses HIV-1 transcription and promotes viral latency by competing with Tat for TAR binding and methylation.38
325548582020Long noncoding RNA LINC00963 induces NOP2 expression by sponging tumor suppressor miR-542-3p to promote metastasis in prostate cancer.20
269064242016Telomerase activates transcription of cyclin D1 gene through an interaction with NOL1.21
269064242016Telomerase activates transcription of cyclin D1 gene through an interaction with NOL1.21
254814152015Nop2 is expressed during proliferation of neural stem cells and in adult mouse and human brain.22
261961252015Eukaryotic rRNA Modification by Yeast 5-Methylcytosine-Methyltransferases and Human Proliferation-Associated Antigen p120.53
254814152015Nop2 is expressed during proliferation of neural stem cells and in adult mouse and human brain.22

Citation

Dessen P

NOP2 (NOP2 nucleolar protein)

Atlas Genet Cytogenet Oncol Haematol. 2012-11-01

Online version: http://atlasgeneticsoncology.org/gene/53027/tumors-explorer/haematological-explorer/img/gene-fusions-explorer/