RC3H2 (ring finger and CCCH-type domains 2)

2012-11-01  

Identity

HGNC
LOCATION
9q33.2
LOCUSID
ALIAS
MNAB,RNF164
FUSION GENES

Other Information

Locus ID:

NCBI: 54542
MIM: 615231
HGNC: 21461
Ensembl: ENSG00000056586

Variants:

dbSNP: 54542
ClinVar: 54542
TCGA: ENSG00000056586
COSMIC: RC3H2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000056586ENST00000335387A6NHN2
ENSG00000056586ENST00000357244Q9HBD1
ENSG00000056586ENST00000357244A0A024R899
ENSG00000056586ENST00000373670Q9HBD1
ENSG00000056586ENST00000373670A0A024R899
ENSG00000056586ENST00000398671Q4VXB2
ENSG00000056586ENST00000423239Q9HBD1
ENSG00000056586ENST00000454740H0Y5D9
ENSG00000056586ENST00000471874Q9HBD1
ENSG00000056586ENST00000498479Q9HBD1

Expression (GTEx)

0
5
10
15
20

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
343452142021Roquin2 suppresses breast cancer progression by inhibiting tumor angiogenesis via selectively destabilizing proangiogenic factors mRNA.5
343452142021Roquin2 suppresses breast cancer progression by inhibiting tumor angiogenesis via selectively destabilizing proangiogenic factors mRNA.5
296957872018Loss of KLHL6 promotes diffuse large B-cell lymphoma growth and survival by stabilizing the mRNA decay factor roquin2.25
296957872018Loss of KLHL6 promotes diffuse large B-cell lymphoma growth and survival by stabilizing the mRNA decay factor roquin2.25
262496982015Structure of human Roquin-2 and its complex with constitutive-decay element RNA.14
264896702015New Insights into the RNA-Binding and E3 Ubiquitin Ligase Activities of Roquins.16
262496982015Structure of human Roquin-2 and its complex with constitutive-decay element RNA.14
264896702015New Insights into the RNA-Binding and E3 Ubiquitin Ligase Activities of Roquins.16

Citation

Dessen P

RC3H2 (ring finger and CCCH-type domains 2)

Atlas Genet Cytogenet Oncol Haematol. 2012-11-01

Online version: http://atlasgeneticsoncology.org/gene/53036/rc3h2