AEN (apoptosis enhancing nuclease)

2012-12-01  

Identity

HGNC
AEN
LOCATION
15q26.1
LOCUSID
64782
ALIAS
ISG20L1,pp12744

Other Information

Locus ID:

NCBI: 64782
MIM: 610177
HGNC: 25722
Ensembl: ENSG00000181026

Variants:

dbSNP: 64782
ClinVar: 64782
TCGA: ENSG00000181026
COSMIC: AEN

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000181026ENST00000332810Q8WTP8
ENSG00000181026ENST00000559528H0YMJ6

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

References

Pubmed IDYearTitleCitations
204299332010ISG20L1 is a p53 family target gene that modulates genotoxic stress-induced autophagy.37
204299332010ISG20L1 is a p53 family target gene that modulates genotoxic stress-induced autophagy.37
182641332008p53 target gene AEN is a nuclear exonuclease required for p53-dependent apoptosis.44
182641332008p53 target gene AEN is a nuclear exonuclease required for p53-dependent apoptosis.44

Citation

Dessen P

AEN (apoptosis enhancing nuclease)

Atlas Genet Cytogenet Oncol Haematol. 2012-12-01

Online version: http://atlasgeneticsoncology.org/gene/53064