ADORA1 (adenosine A1 receptor)

2012-12-01  

Identity

HGNC
ADORA1
LOCATION
1q32.1
LOCUSID
134
ALIAS
RDC7
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 134
MIM: 102775
HGNC: 262
Ensembl: ENSG00000163485

Variants:

dbSNP: 134
ClinVar: 134
TCGA: ENSG00000163485
COSMIC: ADORA1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000163485ENST00000309502P30542
ENSG00000163485ENST00000337894P30542
ENSG00000163485ENST00000367235P30542
ENSG00000163485ENST00000367236P30542
ENSG00000163485ENST00000618295A0A087X173
ENSG00000163485ENST00000640524P30542

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Neuroactive ligand-receptor interactionKEGGko04080
Neuroactive ligand-receptor interactionKEGGhsa04080
Morphine addictionKEGGhsa05032
Morphine addictionKEGGko05032
cGMP-PKG signaling pathwayKEGGhsa04022
cGMP-PKG signaling pathwayKEGGko04022
cAMP signaling pathwayKEGGhsa04024
cAMP signaling pathwayKEGGko04024
Sphingolipid signaling pathwayKEGGhsa04071
Sphingolipid signaling pathwayKEGGko04071
Regulation of lipolysis in adipocytesKEGGhsa04923
Renin secretionKEGGhsa04924
Renin secretionKEGGko04924
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Nucleotide-like (purinergic) receptorsREACTOMER-HSA-418038
Adenosine P1 receptorsREACTOMER-HSA-417973
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (i) signalling eventsREACTOMER-HSA-418594

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA443450AsthmaDiseaseClinicalAnnotationassociatedPD19019667
PA448497aspirinChemicalClinicalAnnotationassociatedPD19019667

References

Pubmed IDYearTitleCitations
385081432024Activation of hepatic adenosine A1 receptor ameliorates MASH via inhibiting SREBPs maturation.0
385081432024Activation of hepatic adenosine A1 receptor ameliorates MASH via inhibiting SREBPs maturation.0
366379882023Comparative Study of Receptor-, Receptor State-, and Membrane-Dependent Cholesterol Binding Sites in A(2A) and A(1) Adenosine Receptors Using Coarse-Grained Molecular Dynamics Simulations.2
366379882023Comparative Study of Receptor-, Receptor State-, and Membrane-Dependent Cholesterol Binding Sites in A(2A) and A(1) Adenosine Receptors Using Coarse-Grained Molecular Dynamics Simulations.2
350464102022Crystal structure of the α(1B)-adrenergic receptor reveals molecular determinants of selective ligand recognition.13
362797182022The ADORA1 mutation linked to early-onset Parkinson's disease alters adenosine A(1)-A(2A) receptor heteromer formation and function.3
350464102022Crystal structure of the α(1B)-adrenergic receptor reveals molecular determinants of selective ligand recognition.13
362797182022The ADORA1 mutation linked to early-onset Parkinson's disease alters adenosine A(1)-A(2A) receptor heteromer formation and function.3
328785602021Expression of ADR-α1, 2 and ADR-β2 in cumulus cell culture of infertile women with polycystic ovary syndrome and poor responder who are a candidate for IVF: the novel strategic role of clonidine in this expression.2
335247702021Systematic deletion of adenosine receptors reveals novel roles in inflammation and pyroptosis in THP-1 macrophages.4
339618542021ADORA1 promotes nasopharyngeal carcinoma cell progression through regulation of PI3K/AKT/GSK-3β/β-catenin signaling.7
345365552021Plasmacytoid dendritic cells recruited by HIF-1α/eADO/ADORA1 signaling induce immunosuppression in hepatocellular carcinoma.26
346716822021Adenosine A1 Receptor Deficiency Aggravates Extracellular Matrix Accumulation in Diabetic Nephropathy through Disturbance of Peritubular Microenvironment.5
328785602021Expression of ADR-α1, 2 and ADR-β2 in cumulus cell culture of infertile women with polycystic ovary syndrome and poor responder who are a candidate for IVF: the novel strategic role of clonidine in this expression.2
335247702021Systematic deletion of adenosine receptors reveals novel roles in inflammation and pyroptosis in THP-1 macrophages.4

Citation

Dessen P

ADORA1 (adenosine A1 receptor)

Atlas Genet Cytogenet Oncol Haematol. 2012-12-01

Online version: http://atlasgeneticsoncology.org/gene/53078/img/favicon/css/lib/dataTables.bootstrap.min.css