Identity
HGNC
LOCATION
10p15.1
LOCUSID
ALIAS
AKR1C-pseudo,BABP,DD,DD-2,DD/BABP,DD2,DDH2,HAKRD,HBAB,MCDR2,SRXY8,TDD
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 1646
MIM: 600450
HGNC: 385
Ensembl: ENSG00000151632
Variants:
dbSNP: 1646
ClinVar: 1646
TCGA: ENSG00000151632
COSMIC: AKR1C2
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000151632 | ENST00000380753 | P52895 |
| ENSG00000151632 | ENST00000421196 | B4DK69 |
| ENSG00000151632 | ENST00000455190 | P52895 |
| ENSG00000151632 | ENST00000604507 | S4R3P0 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36701414 | 2023 | Comprehensive analysis regarding the prognostic significance of downregulated ferroptosis-related gene AKR1C2 in gastric cancer and its underlying roles in immune response. | 0 |
| 37498066 | 2023 | Function, drug resistance and prognostic effect of AKR1C2 in human cancer. | 0 |
| 36701414 | 2023 | Comprehensive analysis regarding the prognostic significance of downregulated ferroptosis-related gene AKR1C2 in gastric cancer and its underlying roles in immune response. | 0 |
| 37498066 | 2023 | Function, drug resistance and prognostic effect of AKR1C2 in human cancer. | 0 |
| 33675863 | 2021 | AKR1C2 and AKR1C3 expression in adipose tissue: Association with body fat distribution and regulatory variants. | 8 |
| 33675863 | 2021 | AKR1C2 and AKR1C3 expression in adipose tissue: Association with body fat distribution and regulatory variants. | 8 |
| 32678482 | 2020 | AKR1C2 acts as a targetable oncogene in esophageal squamous cell carcinoma via activating PI3K/AKT signaling pathway. | 7 |
| 32678482 | 2020 | AKR1C2 acts as a targetable oncogene in esophageal squamous cell carcinoma via activating PI3K/AKT signaling pathway. | 7 |
| 30886237 | 2019 | Ligand entry in human ileal bile acid-binding protein is mediated by histidine protonation. | 3 |
| 31780644 | 2019 | Aldo-keto reductases protect metastatic melanoma from ER stress-independent ferroptosis. | 71 |
| 30886237 | 2019 | Ligand entry in human ileal bile acid-binding protein is mediated by histidine protonation. | 3 |
| 31780644 | 2019 | Aldo-keto reductases protect metastatic melanoma from ER stress-independent ferroptosis. | 71 |
| 29369461 | 2018 | Modulation of AKR1C2 by curcumin decreases testosterone production in prostate cancer. | 24 |
| 29369461 | 2018 | Modulation of AKR1C2 by curcumin decreases testosterone production in prostate cancer. | 24 |
| 28259989 | 2017 | Mefenamic acid enhances anticancer drug sensitivity via inhibition of aldo-keto reductase 1C enzyme activity. | 20 |
Citation
Dessen P
AKR1C2 (aldo-keto reductase family 1 member C2)
Atlas Genet Cytogenet Oncol Haematol. 2012-12-01
Online version: http://atlasgeneticsoncology.org/gene/53095/akr1c2
