Identity
HGNC
LOCATION
10p15.1
LOCUSID
ALIAS
2-ALPHA-HSD,20-ALPHA-HSD,C9,DD1,DD1/DD2,DDH,DDH1,H-37,HAKRC,HBAB,MBAB
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 1645
MIM: 600449
HGNC: 384
Ensembl: ENSG00000187134
Variants:
dbSNP: 1645
ClinVar: 1645
TCGA: ENSG00000187134
COSMIC: AKR1C1
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000187134 | ENST00000380859 | A6NHU4 |
| ENSG00000187134 | ENST00000380872 | Q04828 |
| ENSG00000187134 | ENST00000442997 | H0Y804 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37648943 | 2024 | Regulation of 20α-Hydroxysteroid Dehydrogenase Expression in Term Pregnant Human Myometrium Ex Vivo. | 1 |
| 37648943 | 2024 | Regulation of 20α-Hydroxysteroid Dehydrogenase Expression in Term Pregnant Human Myometrium Ex Vivo. | 1 |
| 36765000 | 2023 | 20α-Hydroxysteroid Dehydrogenase Expression in the Human Myometrium at Term and Preterm Birth: Relationships to Fetal Sex and Maternal Body Mass Index. | 3 |
| 38112954 | 2023 | AKR1C1 and hormone metabolism in lipedema pathogenesis: a computational biology approach. | 1 |
| 36765000 | 2023 | 20α-Hydroxysteroid Dehydrogenase Expression in the Human Myometrium at Term and Preterm Birth: Relationships to Fetal Sex and Maternal Body Mass Index. | 3 |
| 38112954 | 2023 | AKR1C1 and hormone metabolism in lipedema pathogenesis: a computational biology approach. | 1 |
| 36066316 | 2022 | AKR1C1 Protects Corneal Epithelial Cells Against Oxidative Stress-Mediated Ferroptosis in Dry Eye. | 8 |
| 36066316 | 2022 | AKR1C1 Protects Corneal Epithelial Cells Against Oxidative Stress-Mediated Ferroptosis in Dry Eye. | 8 |
| 33170398 | 2021 | AKR1C1 Contributes to Cervical Cancer Progression via Regulating TWIST1 Expression. | 5 |
| 34233738 | 2021 | Aldo-keto reductase family 1 member C1 regulates the osteogenic differentiation of human ASCs by targeting the progesterone receptor. | 0 |
| 34830394 | 2021 | Transcriptomic Profiling Reveals AKR1C1 and AKR1C3 Mediate Cisplatin Resistance in Signet Ring Cell Gastric Carcinoma via Autophagic Cell Death. | 10 |
| 33170398 | 2021 | AKR1C1 Contributes to Cervical Cancer Progression via Regulating TWIST1 Expression. | 5 |
| 34233738 | 2021 | Aldo-keto reductase family 1 member C1 regulates the osteogenic differentiation of human ASCs by targeting the progesterone receptor. | 0 |
| 34830394 | 2021 | Transcriptomic Profiling Reveals AKR1C1 and AKR1C3 Mediate Cisplatin Resistance in Signet Ring Cell Gastric Carcinoma via Autophagic Cell Death. | 10 |
| 31926269 | 2020 | Human dehydrogenase/reductase SDR family member 11 (DHRS11) and aldo-keto reductase 1C isoforms in comparison: Substrate and reaction specificity in the reduction of 11-keto-C(19)-steroids. | 3 |
Citation
Dessen P
AKR1C1 (aldo-keto reductase family 1 member C1)
Atlas Genet Cytogenet Oncol Haematol. 2012-12-01
Online version: http://atlasgeneticsoncology.org/gene/53098/akr1c1
