AIMP2 (aminoacyl tRNA synthetase complex interacting multifunctional protein 2)

2012-12-01  

Identity

HGNC
AIMP2
LOCATION
7p22.1
LOCUSID
7965
ALIAS
HLD17,JTV-1,JTV1,P38
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 7965
MIM: 600859
HGNC: 20609
Ensembl: ENSG00000106305

Variants:

dbSNP: 7965
ClinVar: 7965
TCGA: ENSG00000106305
COSMIC: AIMP2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000106305ENST00000223029Q13155
ENSG00000106305ENST00000223029A0A024QZY1
ENSG00000106305ENST00000395236Q13155
ENSG00000106305ENST00000400479A8MU58
ENSG00000106305ENST00000415999F8WCL2

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
tRNA AminoacylationREACTOMER-HSA-379724
Cytosolic tRNA aminoacylationREACTOMER-HSA-379716
MetabolismREACTOMER-HSA-1430728
Metabolism of amino acids and derivativesREACTOMER-HSA-71291
Selenoamino acid metabolismREACTOMER-HSA-2408522
SeMet incorporation into proteinsREACTOMER-HSA-2408517

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
354872442022Discovery of two distinct aminoacyl-tRNA synthetase complexes anchored to the Plasmodium surface tRNA import protein.2
355461482022AIMP2-DX2 provides therapeutic interface to control KRAS-driven tumorigenesis.4
354872442022Discovery of two distinct aminoacyl-tRNA synthetase complexes anchored to the Plasmodium surface tRNA import protein.2
355461482022AIMP2-DX2 provides therapeutic interface to control KRAS-driven tumorigenesis.4
317924422020Targeting the interaction of AIMP2-DX2 with HSP70 suppresses cancer development.23
324485052020Structural insight into the interaction between p53 TAD1 and AIMP2-DX2 by NMR.1
324711822020An Isoform of the Oncogenic Splice Variant AIMP2-DX2 Detected by a Novel Monoclonal Antibody.1
331280142020Single-cell analysis of AIMP2 splice variants informs on drug sensitivity and prognosis in hematologic cancer.5
317924422020Targeting the interaction of AIMP2-DX2 with HSP70 suppresses cancer development.23
324485052020Structural insight into the interaction between p53 TAD1 and AIMP2-DX2 by NMR.1
324711822020An Isoform of the Oncogenic Splice Variant AIMP2-DX2 Detected by a Novel Monoclonal Antibody.1
331280142020Single-cell analysis of AIMP2 splice variants informs on drug sensitivity and prognosis in hematologic cancer.5
303456332019Label-free molecular probe based on G-quadruplex and strand displacement for sensitive and selective detection and naked eye discrimination of exon 2 deletion of AIMP2.2
307333352019Retractile lysyl-tRNA synthetase-AIMP2 assembly in the human multi-aminoacyl-tRNA synthetase complex.12
303456332019Label-free molecular probe based on G-quadruplex and strand displacement for sensitive and selective detection and naked eye discrimination of exon 2 deletion of AIMP2.2

Citation

Dessen P

AIMP2 (aminoacyl tRNA synthetase complex interacting multifunctional protein 2)

Atlas Genet Cytogenet Oncol Haematol. 2012-12-01

Online version: http://atlasgeneticsoncology.org/gene/53099