DGCR8 (DGCR8 microprocessor complex subunit)

2013-01-01  

Identity

HGNC
DGCR8
LOCATION
22q11.21
LOCUSID
54487
ALIAS
C22orf12,DGCRK6,Gy1,pasha
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 54487
MIM: 609030
HGNC: 2847
Ensembl: ENSG00000128191

Variants:

dbSNP: 54487
ClinVar: 54487
TCGA: ENSG00000128191
COSMIC: DGCR8

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000128191ENST00000351989Q8WYQ5
ENSG00000128191ENST00000383024Q8WYQ5
ENSG00000128191ENST00000407755Q8WYQ5
ENSG00000128191ENST00000457069C9JSD5

Expression (GTEx)

0
10
20
30
40
50
60
70
80
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
Gene Silencing by RNAREACTOMER-HSA-211000
MicroRNA (miRNA) biogenesisREACTOMER-HSA-203927

References

Pubmed IDYearTitleCitations
382528732024Prevalence, Molecular Landscape, and Clinical Impact of DICER1 and DGCR8 Mutated Follicular-Patterned Thyroid Nodules.3
382528732024Prevalence, Molecular Landscape, and Clinical Impact of DICER1 and DGCR8 Mutated Follicular-Patterned Thyroid Nodules.3
368110042023Splice site m(6)A methylation prevents binding of DGCR8 to suppress KRT4 pre-mRNA splicing in oral squamous cell carcinoma.4
369500672023The Ubiquitin-specific Protease USP36 Associates with the Microprocessor Complex and Regulates miRNA Biogenesis by SUMOylating DGCR8.4
368110042023Splice site m(6)A methylation prevents binding of DGCR8 to suppress KRT4 pre-mRNA splicing in oral squamous cell carcinoma.4
369500672023The Ubiquitin-specific Protease USP36 Associates with the Microprocessor Complex and Regulates miRNA Biogenesis by SUMOylating DGCR8.4
360680122022METTL3 contributes to slow transit constipation by regulating miR-30b-5p/PIK3R2/Akt/mTOR signaling cascade through DGCR8.6
363601622022Partial Disturbance of Microprocessor Function in Human Stem Cells Carrying a Heterozygous Mutation in the DGCR8 Gene.0
360680122022METTL3 contributes to slow transit constipation by regulating miR-30b-5p/PIK3R2/Akt/mTOR signaling cascade through DGCR8.6
363601622022Partial Disturbance of Microprocessor Function in Human Stem Cells Carrying a Heterozygous Mutation in the DGCR8 Gene.0
335811092021DGCR8-dependent efficient pri-miRNA processing of human pri-miR-9-2.7
341710972021Whole-genome Sequencing of Follicular Thyroid Carcinomas Reveal Recurrent Mutations in MicroRNA Processing Subunit DGCR8.13
341880372021Non-canonical function of DGCR8 in DNA double-strand break repair signaling and tumor radioresistance.9
342739152021Pathogenic noncoding variants in the neurofibromatosis and schwannomatosis predisposition genes.1
343197632021Coilin enhances phosphorylation and stability of DGCR8 and promotes miRNA biogenesis.3

Citation

Dessen P

DGCR8 (DGCR8 microprocessor complex subunit)

Atlas Genet Cytogenet Oncol Haematol. 2013-01-01

Online version: http://atlasgeneticsoncology.org/gene/53138/tumors-explorer/favicon/favicon/apple-touch-icon.png