EXO5 (exonuclease 5)

2013-01-01  

Identity

HGNC
EXO5
LOCATION
1p34.2
LOCUSID
64789
ALIAS
C1orf176,DEM1,Exo
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 64789
MIM: 618601
HGNC: 26115
Ensembl: ENSG00000164002

Variants:

dbSNP: 64789
ClinVar: 64789
TCGA: ENSG00000164002
COSMIC: EXO5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000164002ENST00000296380Q9H790
ENSG00000164002ENST00000358527Q9H790
ENSG00000164002ENST00000372703Q9H790
ENSG00000164002ENST00000415550X6RK18
ENSG00000164002ENST00000418186X6RCL8
ENSG00000164002ENST00000419161X6RCY3
ENSG00000164002ENST00000420209X6RF29
ENSG00000164002ENST00000432259X6RLK1
ENSG00000164002ENST00000443729X6RCY3

Expression (GTEx)

0
1
2
3
4
5
6
7
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

References

Pubmed IDYearTitleCitations
341977372021EXO5-DNA structure and BLM interactions direct DNA resection critical for ATR-dependent replication restart.21
341977372021EXO5-DNA structure and BLM interactions direct DNA resection critical for ATR-dependent replication restart.21
316160622020Functional deficiency of DNA repair gene EXO5 results in androgen-induced genomic instability and prostate tumorigenesis.8
316160622020Functional deficiency of DNA repair gene EXO5 results in androgen-induced genomic instability and prostate tumorigenesis.8
297614802018Whole exome sequencing identifies PLEC, EXO5 and DNAH7 as novel susceptibility genes in testicular cancer.14
297614802018Whole exome sequencing identifies PLEC, EXO5 and DNAH7 as novel susceptibility genes in testicular cancer.14
230957562012Human exonuclease 5 is a novel sliding exonuclease required for genome stability.14
230957562012Human exonuclease 5 is a novel sliding exonuclease required for genome stability.14

Citation

Dessen P

EXO5 (exonuclease 5)

Atlas Genet Cytogenet Oncol Haematol. 2013-01-01

Online version: http://atlasgeneticsoncology.org/gene/53140/case-report-explorer/img/js/template.js