Identity
HGNC
LOCATION
2q31.2
LOCUSID
ALIAS
DYT16,HSD14,PACT,RAX
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 8575
MIM: 603424
HGNC: 9438
Ensembl: ENSG00000180228
Variants:
dbSNP: 8575
ClinVar: 8575
TCGA: ENSG00000180228
COSMIC: PRKRA
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37264691 | 2023 | PACT inhibits the replication of SARS-CoV-2 through the blockage of GSK-3β-N-nsp3 cascade. | 1 |
| 37264691 | 2023 | PACT inhibits the replication of SARS-CoV-2 through the blockage of GSK-3β-N-nsp3 cascade. | 1 |
| 35075101 | 2022 | SARS-CoV-2 NSP5 and N protein counteract the RIG-I signaling pathway by suppressing the formation of stress granules. | 52 |
| 35625640 | 2022 | DYT-PRKRA Mutation P222L Enhances PACT's Stimulatory Activity on Type I Interferon Induction. | 2 |
| 35974143 | 2022 | PACT promotes the metastasis of basal-like breast cancer through Rac1 SUMOylation and activation. | 5 |
| 35075101 | 2022 | SARS-CoV-2 NSP5 and N protein counteract the RIG-I signaling pathway by suppressing the formation of stress granules. | 52 |
| 35625640 | 2022 | DYT-PRKRA Mutation P222L Enhances PACT's Stimulatory Activity on Type I Interferon Induction. | 2 |
| 35974143 | 2022 | PACT promotes the metastasis of basal-like breast cancer through Rac1 SUMOylation and activation. | 5 |
| 33387379 | 2021 | A tale of two proteins: PACT and PKR and their roles in inflammation. | 28 |
| 33459340 | 2021 | Opposite actions of two dsRNA-binding proteins PACT and TRBP on RIG-I mediated signaling. | 7 |
| 34520479 | 2021 | High-throughput kinome-RNAi screen identifies protein kinase R activator (PACT) as a novel genetic modifier of CUG foci integrity in myotonic dystrophy type 1 (DM1). | 3 |
| 33387379 | 2021 | A tale of two proteins: PACT and PKR and their roles in inflammation. | 28 |
| 33459340 | 2021 | Opposite actions of two dsRNA-binding proteins PACT and TRBP on RIG-I mediated signaling. | 7 |
| 34520479 | 2021 | High-throughput kinome-RNAi screen identifies protein kinase R activator (PACT) as a novel genetic modifier of CUG foci integrity in myotonic dystrophy type 1 (DM1). | 3 |
| 33049316 | 2020 | Dystonia 16 (DYT16) mutations in PACT cause dysregulated PKR activation and eIF2α signaling leading to a compromised stress response. | 13 |
Citation
Dessen P
PRKRA (protein activator of interferon induced protein kinase EIF2AK2)
Atlas Genet Cytogenet Oncol Haematol. 2013-01-01
Online version: http://atlasgeneticsoncology.org/gene/53143/prkra
