Identity
HGNC
LOCATION
5q21.3
LOCUSID
ALIAS
Neurodap1,RNF131
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 9867
HGNC: 17481
Ensembl: ENSG00000198961
Variants:
dbSNP: 9867
ClinVar: 9867
TCGA: ENSG00000198961
COSMIC: PJA2
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000198961 | ENST00000361189 | O43164 |
| ENSG00000198961 | ENST00000361557 | O43164 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38379085 | 2024 | Downregulation of praja2 restrains endocytosis and boosts tyrosine kinase receptors in kidney cancer. | 0 |
| 38802340 | 2024 | Proximal protein landscapes of the type I interferon signaling cascade reveal negative regulation by PJA2. | 0 |
| 38379085 | 2024 | Downregulation of praja2 restrains endocytosis and boosts tyrosine kinase receptors in kidney cancer. | 0 |
| 38802340 | 2024 | Proximal protein landscapes of the type I interferon signaling cascade reveal negative regulation by PJA2. | 0 |
| 33461174 | 2021 | Praja2 suppresses the growth of gastric cancer by ubiquitylation of KSR1 and inhibiting MEK-ERK signal pathways. | 6 |
| 33461174 | 2021 | Praja2 suppresses the growth of gastric cancer by ubiquitylation of KSR1 and inhibiting MEK-ERK signal pathways. | 6 |
| 28345603 | 2017 | PJA2 ubiquitinates the HIV-1 Tat protein with atypical chain linkages to activate viral transcription. | 19 |
| 28345603 | 2017 | PJA2 ubiquitinates the HIV-1 Tat protein with atypical chain linkages to activate viral transcription. | 19 |
| 27195677 | 2016 | praja2 regulates KSR1 stability and mitogenic signaling. | 18 |
| 27195677 | 2016 | praja2 regulates KSR1 stability and mitogenic signaling. | 18 |
| 23652010 | 2013 | Proteolysis of MOB1 by the ubiquitin ligase praja2 attenuates Hippo signalling and supports glioblastoma growth. | 64 |
| 23931849 | 2013 | Detection of novel paraja ring finger 2-fer tyrosine kinase mRNA chimeras is associated with poor postoperative prognosis in non-small cell lung cancer. | 8 |
| 23652010 | 2013 | Proteolysis of MOB1 by the ubiquitin ligase praja2 attenuates Hippo signalling and supports glioblastoma growth. | 64 |
| 23931849 | 2013 | Detection of novel paraja ring finger 2-fer tyrosine kinase mRNA chimeras is associated with poor postoperative prognosis in non-small cell lung cancer. | 8 |
| 22948757 | 2012 | Expression of the ring ligase PRAJA2 in thyroid cancer. | 15 |
Citation
Dessen P
PJA2 (praja ring finger ubiquitin ligase 2)
Atlas Genet Cytogenet Oncol Haematol. 2013-02-01
Online version: http://atlasgeneticsoncology.org/gene/53166/pja2
