SLC5A6 (solute carrier family 5 member 6)

2013-02-01  

Identity

HGNC
LOCATION
2p23.3
LOCUSID
ALIAS
NERIB,SMVT
FUSION GENES

Other Information

Locus ID:

NCBI: 8884
MIM: 604024
HGNC: 11041
Ensembl: ENSG00000138074

Variants:

dbSNP: 8884
ClinVar: 8884
TCGA: ENSG00000138074
COSMIC: SLC5A6

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000138074ENST00000310574Q9Y289
ENSG00000138074ENST00000401463E7EW78
ENSG00000138074ENST00000408041Q9Y289
ENSG00000138074ENST00000412471E7EMX0
ENSG00000138074ENST00000414408E7EW41
ENSG00000138074ENST00000426119E7ERE1
ENSG00000138074ENST00000428518E7EP02
ENSG00000138074ENST00000430186E7EXC0
ENSG00000138074ENST00000432106E7ENG0
ENSG00000138074ENST00000442731Q9HD19
ENSG00000138074ENST00000445802E7ENN0

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90

Pathways

PathwaySourceExternal ID
Vitamin digestion and absorptionKEGGko04977
Vitamin digestion and absorptionKEGGhsa04977
Transmembrane transport of small moleculesREACTOMER-HSA-382551
SLC-mediated transmembrane transportREACTOMER-HSA-425407
Transport of vitamins, nucleosides, and related moleculesREACTOMER-HSA-425397
MetabolismREACTOMER-HSA-1430728
Metabolism of vitamins and cofactorsREACTOMER-HSA-196854
Metabolism of water-soluble vitamins and cofactorsREACTOMER-HSA-196849
Vitamin B5 (pantothenate) metabolismREACTOMER-HSA-199220
Biotin transport and metabolismREACTOMER-HSA-196780

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
380123942024Novel missense variants cause intermediate phenotypes in the phenotypic spectrum of SLC5A6-related disorders.1
380123942024Novel missense variants cause intermediate phenotypes in the phenotypic spectrum of SLC5A6-related disorders.1
373910292023A novel SLC5A6 homozygous variant in a family with multivitamin-dependent neurometabolic disorder: Phenotype expansion and long-term follow-up.3
380362782023Novel SLC5A6 mutations lead to B lymphocyte maturation defects with metabolic abnormality rescuable by biotin replenishment.3
373910292023A novel SLC5A6 homozygous variant in a family with multivitamin-dependent neurometabolic disorder: Phenotype expansion and long-term follow-up.3
380362782023Novel SLC5A6 mutations lead to B lymphocyte maturation defects with metabolic abnormality rescuable by biotin replenishment.3
350135512022Novel biallelic variants expand the SLC5A6-related phenotypic spectrum.6
350135512022Novel biallelic variants expand the SLC5A6-related phenotypic spectrum.6
318942662020Integrated profiling identifies SLC5A6 and MFAP2 as novel diagnostic and prognostic biomarkers in gastric cancer patients.14
318942662020Integrated profiling identifies SLC5A6 and MFAP2 as novel diagnostic and prognostic biomarkers in gastric cancer patients.14
280528642017Lipopolysaccharide inhibits colonic biotin uptake via interference with membrane expression of its transporter: a role for a casein kinase 2-mediated pathway.7
280528642017Lipopolysaccharide inhibits colonic biotin uptake via interference with membrane expression of its transporter: a role for a casein kinase 2-mediated pathway.7
258099832015Major involvement of Na(+) -dependent multivitamin transporter (SLC5A6/SMVT) in uptake of biotin and pantothenic acid by human brain capillary endothelial cells.33
259719662015Interaction of α-Lipoic Acid with the Human Na+/Multivitamin Transporter (hSMVT).14
259994272015Salmonella infection inhibits intestinal biotin transport: cellular and molecular mechanisms.8

Citation

Dessen P

SLC5A6 (solute carrier family 5 member 6)

Atlas Genet Cytogenet Oncol Haematol. 2013-02-01

Online version: http://atlasgeneticsoncology.org/gene/53168/slc5a6