Identity
HGNC
LOCATION
22q12.3
LOCUSID
ALIAS
FOX2,Fox-2,HNRBP2,HRNBP2,RBM9,RTA,dJ106I20.3,fxh
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 23543
MIM: 612149
HGNC: 9906
Ensembl: ENSG00000100320
Variants:
dbSNP: 23543
ClinVar: 23543
TCGA: ENSG00000100320
COSMIC: RBFOX2
RNA/Proteins
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Signal Transduction | REACTOME | R-HSA-162582 |
| Signaling by FGFR | REACTOME | R-HSA-190236 |
| Signaling by FGFR2 | REACTOME | R-HSA-5654738 |
| FGFR2 alternative splicing | REACTOME | R-HSA-6803529 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36949200 | 2023 | RBFOX2 modulates a metastatic signature of alternative splicing in pancreatic cancer. | 19 |
| 37264873 | 2023 | RBFOX2 confers tumor growth by PI3K/AKT and MAPK signaling in gastric cancer. | 0 |
| 37822160 | 2023 | FBXO7 Confers Mesenchymal Properties and Chemoresistance in Glioblastoma by Controlling Rbfox2-Mediated Alternative Splicing. | 4 |
| 38114498 | 2023 | RBFOX2 deregulation promotes pancreatic cancer progression and metastasis through alternative splicing. | 3 |
| 36949200 | 2023 | RBFOX2 modulates a metastatic signature of alternative splicing in pancreatic cancer. | 19 |
| 37264873 | 2023 | RBFOX2 confers tumor growth by PI3K/AKT and MAPK signaling in gastric cancer. | 0 |
| 37822160 | 2023 | FBXO7 Confers Mesenchymal Properties and Chemoresistance in Glioblastoma by Controlling Rbfox2-Mediated Alternative Splicing. | 4 |
| 38114498 | 2023 | RBFOX2 deregulation promotes pancreatic cancer progression and metastasis through alternative splicing. | 3 |
| 35269658 | 2022 | The Splicing of the Mitochondrial Calcium Uniporter Genuine Activator MICU1 Is Driven by RBFOX2 Splicing Factor during Myogenic Differentiation. | 2 |
| 35404107 | 2022 | Alternative Splicing of the Aryl Hydrocarbon Receptor Nuclear Translocator (ARNT) Is Regulated by RBFOX2 in Lymphoid Malignancies. | 6 |
| 36466711 | 2022 | The Role of Alternative Splicing Factors hnRNP G and Fox-2 in the Progression and Prognosis of Esophageal Cancer. | 0 |
| 35269658 | 2022 | The Splicing of the Mitochondrial Calcium Uniporter Genuine Activator MICU1 Is Driven by RBFOX2 Splicing Factor during Myogenic Differentiation. | 2 |
| 35404107 | 2022 | Alternative Splicing of the Aryl Hydrocarbon Receptor Nuclear Translocator (ARNT) Is Regulated by RBFOX2 in Lymphoid Malignancies. | 6 |
| 36466711 | 2022 | The Role of Alternative Splicing Factors hnRNP G and Fox-2 in the Progression and Prognosis of Esophageal Cancer. | 0 |
| 34009296 | 2021 | ERG transcription factors have a splicing regulatory function involving RBFOX2 that is altered in the EWS-FLI1 oncogenic fusion. | 6 |
Citation
Dessen P
RBFOX2 (RNA binding fox-1 homolog 2)
Atlas Genet Cytogenet Oncol Haematol. 2013-03-01
Online version: http://atlasgeneticsoncology.org/gene/53203/rbfox2
