TACR2 (tachykinin receptor 2)

2013-04-01  

Identity

HGNC
LOCATION
10q22.1
LOCUSID
ALIAS
NK2R,NKNAR,SKR,TAC2R

Other Information

Locus ID:

NCBI: 6865
MIM: 162321
HGNC: 11527
Ensembl: ENSG00000075073

Variants:

dbSNP: 6865
ClinVar: 6865
TCGA: ENSG00000075073
COSMIC: TACR2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000075073ENST00000373306P21452
ENSG00000075073ENST00000373307A6NEW7
ENSG00000075073ENST00000619173A0A087WZ80

Expression (GTEx)

0
50
100
150
200
250

Pathways

PathwaySourceExternal ID
Calcium signaling pathwayKEGGko04020
Neuroactive ligand-receptor interactionKEGGko04080
Calcium signaling pathwayKEGGhsa04020
Neuroactive ligand-receptor interactionKEGGhsa04080
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Peptide ligand-binding receptorsREACTOMER-HSA-375276
Tachykinin receptors bind tachykininsREACTOMER-HSA-380095
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (q) signalling eventsREACTOMER-HSA-416476
Gastrin-CREB signalling pathway via PKC and MAPKREACTOMER-HSA-881907

References

Pubmed IDYearTitleCitations
379446182023Deciphering specificity and cross-reactivity in tachykinin NK1 and NK2 receptors.0
379446182023Deciphering specificity and cross-reactivity in tachykinin NK1 and NK2 receptors.0
355610882022IFN-α/β-mediated NK2R expression is related to the malignancy of colon cancer cells.6
355610882022IFN-α/β-mediated NK2R expression is related to the malignancy of colon cancer cells.6
326006682020Hemokinin-1 and substance P stimulate production of inflammatory cytokines and chemokines in human colonic mucosa via both NK(1) and NK(2) tachykinin receptors.4
326006682020Hemokinin-1 and substance P stimulate production of inflammatory cytokines and chemokines in human colonic mucosa via both NK(1) and NK(2) tachykinin receptors.4
271460342016Expression of Tachykinins and Tachykinin Receptors and Interaction with Kisspeptin in Human Granulosa and Cumulus Cells.7
274565492016Altered expression of the tachykinins substance P/neurokinin A/hemokinin-1 and their preferred neurokinin 1/neurokinin 2 receptors in uterine leiomyomata.7
280308662016Increase of Mast Cell-Nerve Association and Neuropeptide Receptor Expression on Mast Cells in Perennial Allergic Rhinitis.14
271460342016Expression of Tachykinins and Tachykinin Receptors and Interaction with Kisspeptin in Human Granulosa and Cumulus Cells.7
274565492016Altered expression of the tachykinins substance P/neurokinin A/hemokinin-1 and their preferred neurokinin 1/neurokinin 2 receptors in uterine leiomyomata.7
280308662016Increase of Mast Cell-Nerve Association and Neuropeptide Receptor Expression on Mast Cells in Perennial Allergic Rhinitis.14
263718422015Neuropeptide signaling through neurokinin-1 and neurokinin-2 receptors augments antigen presentation by human dendritic cells.9
263718422015Neuropeptide signaling through neurokinin-1 and neurokinin-2 receptors augments antigen presentation by human dendritic cells.9
231422112013Recurrent major depressive disorder: Imbalance of neurokinin (NK)-1 and NK-2 receptor expression in monocytes.3

Citation

Dessen P

TACR2 (tachykinin receptor 2)

Atlas Genet Cytogenet Oncol Haematol. 2013-04-01

Online version: http://atlasgeneticsoncology.org/gene/53237/tacr2