GDPD5 (glycerophosphodiester phosphodiesterase domain containing 5)

2013-05-01  

Identity

HGNC
GDPD5
LOCATION
11q13.4
LOCUSID
81544
ALIAS
GDE2,PP1665
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 81544
MIM: 609632
HGNC: 28804
Ensembl: ENSG00000158555

Variants:

dbSNP: 81544
ClinVar: 81544
TCGA: ENSG00000158555
COSMIC: GDPD5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000158555ENST00000336898Q8WTR4
ENSG00000158555ENST00000443276Q8NDN3
ENSG00000158555ENST00000526177Q8WTR4
ENSG00000158555ENST00000527820Q8NDN3
ENSG00000158555ENST00000529721Q8WTR4
ENSG00000158555ENST00000532435E9PJU5
ENSG00000158555ENST00000533784Q8WTR4
ENSG00000158555ENST00000533805Q8WTR4
ENSG00000158555ENST00000534322H0YEF5

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Phospholipid metabolismREACTOMER-HSA-1483257
PI MetabolismREACTOMER-HSA-1483255
Glycerophospholipid catabolismREACTOMER-HSA-6814848

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
385759652024Loss of GDE2 leads to complex behavioral changes including memory impairment.1
385759652024Loss of GDE2 leads to complex behavioral changes including memory impairment.1
337314362021GDE2-RECK controls ADAM10 α-secretase-mediated cleavage of amyloid precursor protein.8
337970912021Circ_0007142 downregulates miR-874-3p-mediated GDPD5 on colorectal cancer cells.28
337314362021GDE2-RECK controls ADAM10 α-secretase-mediated cleavage of amyloid precursor protein.8
337970912021Circ_0007142 downregulates miR-874-3p-mediated GDPD5 on colorectal cancer cells.28
292032332018Glycerophosphodiesterase GDE2/GDPD5 affects pancreas differentiation in zebrafish.5
296359042018GDPD5, a target of miR-195-5p, is associated with metastasis and chemoresistance in colorectal cancer.29
292032332018Glycerophosphodiesterase GDE2/GDPD5 affects pancreas differentiation in zebrafish.5
296359042018GDPD5, a target of miR-195-5p, is associated with metastasis and chemoresistance in colorectal cancer.29
276930462016Glycerophosphodiesterase GDE2 Promotes Neuroblastoma Differentiation through Glypican Release and Is a Marker of Clinical Outcome.31
276930462016Glycerophosphodiesterase GDE2 Promotes Neuroblastoma Differentiation through Glypican Release and Is a Marker of Clinical Outcome.31
222790382012Glycerophosphodiester phosphodiesterase domain containing 5 (GDPD5) expression correlates with malignant choline phospholipid metabolite profiles in human breast cancer.32
222790382012Glycerophosphodiester phosphodiesterase domain containing 5 (GDPD5) expression correlates with malignant choline phospholipid metabolite profiles in human breast cancer.32
175786822008Cloning and characterization of a human GDPD domain-containing protein GDPD5.8

Citation

Dessen P

GDPD5 (glycerophosphodiester phosphodiesterase domain containing 5)

Atlas Genet Cytogenet Oncol Haematol. 2013-05-01

Online version: http://atlasgeneticsoncology.org/gene/53254