PARP6 (poly(ADP-ribose) polymerase family member 6)

2013-05-01  

Identity

HGNC
PARP6
LOCATION
15q23
LOCUSID
56965
ALIAS
ARTD17,PARP-6-B1,PARP-6-C,pART17
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 56965
HGNC: 26921
Ensembl: ENSG00000137817

Variants:

dbSNP: 56965
ClinVar: 56965
TCGA: ENSG00000137817
COSMIC: PARP6

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000137817ENST00000260376Q2NL67
ENSG00000137817ENST00000260376J7MDH3
ENSG00000137817ENST00000287196Q2NL67
ENSG00000137817ENST00000287196A0A024R5Z4
ENSG00000137817ENST00000419739F5H3B4
ENSG00000137817ENST00000564610H3BRZ3
ENSG00000137817ENST00000565443H3BRR4
ENSG00000137817ENST00000565999H3BTE2
ENSG00000137817ENST00000566844H3BTI3
ENSG00000137817ENST00000567042H3BQ70
ENSG00000137817ENST00000567263H3BUQ6
ENSG00000137817ENST00000567440H3BMA3
ENSG00000137817ENST00000567974H3BQK2
ENSG00000137817ENST00000568360H3BUY2
ENSG00000137817ENST00000569173H3BSK7
ENSG00000137817ENST00000569795Q2NL67
ENSG00000137817ENST00000569795A0A024R5Z4
ENSG00000137817ENST00000569890H3BQM7
ENSG00000137817ENST00000616176A0A087X1Y8

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
MetabolismREACTOMER-HSA-1430728
Metabolism of vitamins and cofactorsREACTOMER-HSA-196854
Metabolism of water-soluble vitamins and cofactorsREACTOMER-HSA-196849
Nicotinate metabolismREACTOMER-HSA-196807
Nicotinamide salvagingREACTOMER-HSA-197264

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
340674182021Characterization of PARP6 Function in Knockout Mice and Patients with Developmental Delay.7
340674182021Characterization of PARP6 Function in Knockout Mice and Patients with Developmental Delay.7
282600872017Knockdown of PARP6 or survivin promotes cell apoptosis and inhibits cell invasion of colorectal adenocarcinoma cells.9
282600872017Knockdown of PARP6 or survivin promotes cell apoptosis and inhibits cell invasion of colorectal adenocarcinoma cells.9
269343152016PARP6 acts as a tumor suppressor via downregulating Survivin expression in colorectal cancer.21
269343152016PARP6 acts as a tumor suppressor via downregulating Survivin expression in colorectal cancer.21
230420382012PARP6, a mono(ADP-ribosyl) transferase and a negative regulator of cell proliferation, is involved in colorectal cancer development.27
230420382012PARP6, a mono(ADP-ribosyl) transferase and a negative regulator of cell proliferation, is involved in colorectal cancer development.27
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.78
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.78

Citation

Dessen P

PARP6 (poly(ADP-ribose) polymerase family member 6)

Atlas Genet Cytogenet Oncol Haematol. 2013-05-01

Online version: http://atlasgeneticsoncology.org/gene/53270/parp6