RALGAPA2 (Ral GTPase activating protein catalytic subunit alpha 2)

2013-05-01  

Identity

HGNC
RALGAPA2
LOCATION
20p11.23
LOCUSID
57186
ALIAS
AS250,C20orf74,bA287B20.1,dJ1049G11,dJ1049G11.4,p220
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 57186
MIM: 618836
HGNC: 16207
Ensembl: ENSG00000188559

Variants:

dbSNP: 57186
ClinVar: 57186
TCGA: ENSG00000188559
COSMIC: RALGAPA2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000188559ENST00000202677Q2PPJ7
ENSG00000188559ENST00000427175H7BZA8
ENSG00000188559ENST00000430436H7C1F9
ENSG00000188559ENST00000495793A0A3B3IS41
ENSG00000188559ENST00000620717A0A087WYA8

Expression (GTEx)

0
5
10
15
20
25
30
35
40
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Translocation of GLUT4 to the plasma membraneREACTOMER-HSA-1445148

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
328808252020The interaction between MALAT1 target, miR-143-3p, and RALGAPA2 is affected by functional SNP rs3827693 in breast cancer.11
328808252020The interaction between MALAT1 target, miR-143-3p, and RALGAPA2 is affected by functional SNP rs3827693 in breast cancer.11
310582832019Downregulation of RalGTPase-activating protein promotes invasion of prostatic epithelial cells and progression from intraepithelial neoplasia to cancer during prostate carcinogenesis.10
313290422019Ral GTPase Activation by Downregulation of RalGAP Enhances Oral Squamous Cell Carcinoma Progression.10
310582832019Downregulation of RalGTPase-activating protein promotes invasion of prostatic epithelial cells and progression from intraepithelial neoplasia to cancer during prostate carcinogenesis.10
313290422019Ral GTPase Activation by Downregulation of RalGAP Enhances Oral Squamous Cell Carcinoma Progression.10
224507452013Downregulation of Ral GTPase-activating protein promotes tumor invasion and metastasis of bladder cancer.32
224507452013Downregulation of Ral GTPase-activating protein promotes tumor invasion and metastasis of bladder cancer.32
164903462006Adipocytes contain a novel complex similar to the tuberous sclerosis complex.13
164903462006Adipocytes contain a novel complex similar to the tuberous sclerosis complex.13

Citation

Dessen P

RALGAPA2 (Ral GTPase activating protein catalytic subunit alpha 2)

Atlas Genet Cytogenet Oncol Haematol. 2013-05-01

Online version: http://atlasgeneticsoncology.org/gene/53283/gene-fusions-explorer/tumors-explorer/tumors-explorer/