Identity
HGNC
LOCATION
1p31.3
LOCUSID
ALIAS
C1orf139,EVI,GPR177,MRP,mig-14
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 79971
MIM: 611514
HGNC: 30238
Ensembl: ENSG00000116729
Variants:
dbSNP: 79971
ClinVar: 79971
TCGA: ENSG00000116729
COSMIC: WLS
RNA/Proteins
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Signal Transduction | REACTOME | R-HSA-162582 |
| Signaling by Wnt | REACTOME | R-HSA-195721 |
| WNT ligand biogenesis and trafficking | REACTOME | R-HSA-3238698 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36374649 | 2023 | Mutations in the WLS are associated with dental anomalies, torus palatinus, and torus mandibularis. | 7 |
| 36763105 | 2023 | The role of Evi/Wntless in exporting Wnt proteins. | 0 |
| 37005218 | 2023 | Compound heterozygous variants in WLS gene causes Zaki syndrome. | 0 |
| 37106064 | 2023 | Expanding the phenotypic spectrum and clinical severity associated with WLS gene. | 0 |
| 36374649 | 2023 | Mutations in the WLS are associated with dental anomalies, torus palatinus, and torus mandibularis. | 7 |
| 36763105 | 2023 | The role of Evi/Wntless in exporting Wnt proteins. | 0 |
| 37005218 | 2023 | Compound heterozygous variants in WLS gene causes Zaki syndrome. | 0 |
| 37106064 | 2023 | Expanding the phenotypic spectrum and clinical severity associated with WLS gene. | 0 |
| 35385340 | 2022 | GPR177 in A-fiber sensory neurons drives diabetic neuropathic pain via WNT-mediated TRPV1 activation. | 22 |
| 35385340 | 2022 | GPR177 in A-fiber sensory neurons drives diabetic neuropathic pain via WNT-mediated TRPV1 activation. | 22 |
| 33357447 | 2021 | Structural Basis of WLS/Evi-Mediated Wnt Transport and Secretion. | 24 |
| 34015469 | 2021 | Responses of Porcupine and Wntless proteins to oxidative, hypoxic and endoplasmic reticulum stresses. | 2 |
| 34315898 | 2021 | Cryo-EM structure of human Wntless in complex with Wnt3a. | 9 |
| 33357447 | 2021 | Structural Basis of WLS/Evi-Mediated Wnt Transport and Secretion. | 24 |
| 34015469 | 2021 | Responses of Porcupine and Wntless proteins to oxidative, hypoxic and endoplasmic reticulum stresses. | 2 |
Citation
Dessen P
WLS (Wnt ligand secretion mediator)
Atlas Genet Cytogenet Oncol Haematol. 2013-05-01
Online version: http://atlasgeneticsoncology.org/gene/53306/wls
