SCAP (SREBF chaperone)

2013-06-01  

Identity

HGNC
SCAP
LOCATION
3p21.31
LOCUSID
22937
ALIAS
-
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 22937
MIM: 601510
HGNC: 30634
Ensembl: ENSG00000114650

Variants:

dbSNP: 22937
ClinVar: 22937
TCGA: ENSG00000114650
COSMIC: SCAP

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000114650ENST00000265565Q12770
ENSG00000114650ENST00000320017F8W9W7
ENSG00000114650ENST00000416208F8WDP3
ENSG00000114650ENST00000416847C9JQ35
ENSG00000114650ENST00000428413F8WEH8
ENSG00000114650ENST00000441517F8W921
ENSG00000114650ENST00000448217C9JFY0
ENSG00000114650ENST00000495603D6RA39
ENSG00000114650ENST00000545718A0A0A0MTG6
ENSG00000114650ENST00000648151Q12770

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Regulation of cholesterol biosynthesis by SREBP (SREBF)REACTOMER-HSA-1655829

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA444516HypercholesterolemiaDiseaseClinicalAnnotationassociatedPD16158080
PA448500atorvastatinChemicalClinicalAnnotationassociatedPD18435918
PA451363simvastatinChemicalClinicalAnnotationassociatedPD16158080

References

Pubmed IDYearTitleCitations
379793952024SARS-CoV-2 nucleocapsid protein promotes TMAO-induced NLRP3 inflammasome activation by SCAP-SREBP signaling pathway.1
382561812024The Role of SCAP/SREBP as Central Regulators of Lipid Metabolism in Hepatic Steatosis.5
379793952024SARS-CoV-2 nucleocapsid protein promotes TMAO-induced NLRP3 inflammasome activation by SCAP-SREBP signaling pathway.1
382561812024The Role of SCAP/SREBP as Central Regulators of Lipid Metabolism in Hepatic Steatosis.5
374373692023Deficiency of SCAP inhibits HBV pathogenesis via activation of the interferon signaling pathway.1
374373692023Deficiency of SCAP inhibits HBV pathogenesis via activation of the interferon signaling pathway.1
324329432021Discovery of a potent SCAP degrader that ameliorates HFD-induced obesity, hyperlipidemia and insulin resistance via an autophagy-independent lysosomal pathway.21
331563282021The ER cholesterol sensor SCAP promotes CARTS biogenesis at ER-Golgi membrane contact sites.16
334464832021A structure of human Scap bound to Insig-2 suggests how their interaction is regulated by sterols.30
341925492021Structural basis for sterol sensing by Scap and Insig.11
344873772021PKM2-TMEM33 axis regulates lipid homeostasis in cancer cells by controlling SCAP stability.14
324329432021Discovery of a potent SCAP degrader that ameliorates HFD-induced obesity, hyperlipidemia and insulin resistance via an autophagy-independent lysosomal pathway.21
331563282021The ER cholesterol sensor SCAP promotes CARTS biogenesis at ER-Golgi membrane contact sites.16
334464832021A structure of human Scap bound to Insig-2 suggests how their interaction is regulated by sterols.30
341925492021Structural basis for sterol sensing by Scap and Insig.11

Citation

Dessen P

SCAP (SREBF chaperone)

Atlas Genet Cytogenet Oncol Haematol. 2013-06-01

Online version: http://atlasgeneticsoncology.org/gene/53340