PAPSS2 (3-phosphoadenosine 5-phosphosulfate synthase 2)

2013-06-01  

Identity

HGNC
PAPSS2
LOCATION
10q23.2
LOCUSID
9060
ALIAS
ATPSK2,BCYM4,SK2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 9060
MIM: 603005
HGNC: 8604
Ensembl: ENSG00000198682

Variants:

dbSNP: 9060
ClinVar: 9060
TCGA: ENSG00000198682
COSMIC: PAPSS2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000198682ENST00000361175O95340
ENSG00000198682ENST00000361175Q5TB52
ENSG00000198682ENST00000456849O95340

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Purine metabolismKEGGko00230
Selenocompound metabolismKEGGko00450
Sulfur metabolismKEGGko00920
Purine metabolismKEGGhsa00230
Selenocompound metabolismKEGGhsa00450
Sulfur metabolismKEGGhsa00920
Metabolic pathwaysKEGGhsa01100
MetabolismREACTOMER-HSA-1430728
Metabolism of carbohydratesREACTOMER-HSA-71387
Glycosaminoglycan metabolismREACTOMER-HSA-1630316
Transport and synthesis of PAPSREACTOMER-HSA-174362
Metabolism of amino acids and derivativesREACTOMER-HSA-71291
Biological oxidationsREACTOMER-HSA-211859
Phase II conjugationREACTOMER-HSA-156580
Cytosolic sulfonation of small moleculesREACTOMER-HSA-156584
Selenoamino acid metabolismREACTOMER-HSA-2408522
Metabolism of ingested H2SeO4 and H2SeO3 into H2SeREACTOMER-HSA-2408550

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
cartilage
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
380840482024Bone Phenotype is Always Present But Androgen Excess is Less Frequently Seen in PAPSS2 Deficiency.0
380840482024Bone Phenotype is Always Present But Androgen Excess is Less Frequently Seen in PAPSS2 Deficiency.0
372076442023Redox switching mechanism of the adenosine 5'-phosphosulfate kinase domain (APSK2) of human PAPS synthase 2.0
372076442023Redox switching mechanism of the adenosine 5'-phosphosulfate kinase domain (APSK2) of human PAPS synthase 2.0
348185832022Structural basis for the substrate recognition mechanism of ATP-sulfurylase domain of human PAPS synthase 2.4
352612002022Identification of variants in ACAN and PAPSS2 leading to spondyloepi(meta)physeal dysplasias in four Chinese families.3
348185832022Structural basis for the substrate recognition mechanism of ATP-sulfurylase domain of human PAPS synthase 2.4
352612002022Identification of variants in ACAN and PAPSS2 leading to spondyloepi(meta)physeal dysplasias in four Chinese families.3
338194832021Intestinal Sulfation Is Essential to Protect Against Colitis and Colonic Carcinogenesis.22
338194832021Intestinal Sulfation Is Essential to Protect Against Colitis and Colonic Carcinogenesis.22
299551242019Enhanced PAPSS2/VCAN sulfation axis is essential for Snail-mediated breast cancer cell migration and metastasis.52
313135122019PAPSS2-related brachyolmia: Clinical and radiological phenotype in 18 new cases.10
299551242019Enhanced PAPSS2/VCAN sulfation axis is essential for Snail-mediated breast cancer cell migration and metastasis.52
313135122019PAPSS2-related brachyolmia: Clinical and radiological phenotype in 18 new cases.10
297432392018Human DHEA sulfation requires direct interaction between PAPS synthase 2 and DHEA sulfotransferase SULT2A1.15

Citation

Dessen P

PAPSS2 (3-phosphoadenosine 5-phosphosulfate synthase 2)

Atlas Genet Cytogenet Oncol Haematol. 2013-06-01

Online version: http://atlasgeneticsoncology.org/gene/53351