CTSV (cathepsin V)

2013-07-01  

Identity

HGNC
CTSV
LOCATION
9q22.33
LOCUSID
1515
ALIAS
CATL2,CTSL2,CTSU

Other Information

Locus ID:

NCBI: 1515
MIM: 603308
HGNC: 2538
Ensembl: ENSG00000136943

Variants:

dbSNP: 1515
ClinVar: 1515
TCGA: ENSG00000136943
COSMIC: CTSV

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000136943ENST00000259470O60911
ENSG00000136943ENST00000259470A0A024R141
ENSG00000136943ENST00000538255O60911
ENSG00000136943ENST00000538255A0A024R141

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
ApoptosisKEGGko04210
ApoptosisKEGGhsa04210
LysosomeKEGGko04142
LysosomeKEGGhsa04142
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing-Cross presentationREACTOMER-HSA-1236975
Endosomal/Vacuolar pathwayREACTOMER-HSA-1236977
MHC class II antigen presentationREACTOMER-HSA-2132295
Innate Immune SystemREACTOMER-HSA-168249
Toll-Like Receptors CascadesREACTOMER-HSA-168898
Trafficking and processing of endosomal TLRREACTOMER-HSA-1679131
Extracellular matrix organizationREACTOMER-HSA-1474244
Collagen formationREACTOMER-HSA-1474290
Assembly of collagen fibrils and other multimeric structuresREACTOMER-HSA-2022090
Degradation of the extracellular matrixREACTOMER-HSA-1474228
Activation of Matrix MetalloproteinasesREACTOMER-HSA-1592389

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
380512852024Cathepsin V is correlated with the prognosis and tumor microenvironment in liver cancer.1
380512852024Cathepsin V is correlated with the prognosis and tumor microenvironment in liver cancer.1
353058072022Cathepsin V: Molecular characteristics and significance in health and disease.12
354438632022CTSV (cathepsin V) promotes bladder cancer progression by increasing NF-κB activity.3
353058072022Cathepsin V: Molecular characteristics and significance in health and disease.12
354438632022CTSV (cathepsin V) promotes bladder cancer progression by increasing NF-κB activity.3
314442382020Prognostic significance of cathepsin V (CTSV/CTSL2) in breast ductal carcinoma in situ.21
320075792020Expression of elastolytic cathepsins in human skin and their involvement in age-dependent elastin degradation.11
329109882020Significance of nuclear cathepsin V in normal thyroid epithelial and carcinoma cells.11
329126292020HMGB1 mediates homocysteine-induced endothelial cells pyroptosis via cathepsin V-dependent pathway.10
329186812020Cathepsin V Mediates the Tazarotene-induced Gene 1-induced Reduction in Invasion in Colorectal Cancer Cells.12
332981392020Cathepsin V suppresses GATA3 protein expression in luminal A breast cancer.17
314442382020Prognostic significance of cathepsin V (CTSV/CTSL2) in breast ductal carcinoma in situ.21
320075792020Expression of elastolytic cathepsins in human skin and their involvement in age-dependent elastin degradation.11
329109882020Significance of nuclear cathepsin V in normal thyroid epithelial and carcinoma cells.11

Citation

Dessen P

CTSV (cathepsin V)

Atlas Genet Cytogenet Oncol Haematol. 2013-07-01

Online version: http://atlasgeneticsoncology.org/gene/53451