SIRT5 (sirtuin 5)

2013-08-01  

Identity

HGNC
SIRT5
LOCATION
6p23
LOCUSID
23408
ALIAS
SIR2L5

Other Information

Locus ID:

NCBI: 23408
MIM: 604483
HGNC: 14933
Ensembl: ENSG00000124523

Variants:

dbSNP: 23408
ClinVar: 23408
TCGA: ENSG00000124523
COSMIC: SIRT5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000124523ENST00000359782Q9NXA8
ENSG00000124523ENST00000379250Q7Z3A0
ENSG00000124523ENST00000379262Q9NXA8
ENSG00000124523ENST00000397350Q9NXA8
ENSG00000124523ENST00000606117Q9NXA8
ENSG00000124523ENST00000606117A0A024R012
ENSG00000124523ENST00000606427U3KQT8

Expression (GTEx)

0
5
10
15
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
378907192024SIRT5 rs12216101 T>G variant is associated with liver damage and mitochondrial dysfunction in patients with non-alcoholic fatty liver disease.2
381129792024Sirtuin 5-mediated deacetylation of TAZ at K54 promotes melanoma development.2
385323592024SIRT5 promote malignant advancement of chordoma by regulating the desuccinylation of c-myc.1
378907192024SIRT5 rs12216101 T>G variant is associated with liver damage and mitochondrial dysfunction in patients with non-alcoholic fatty liver disease.2
381129792024Sirtuin 5-mediated deacetylation of TAZ at K54 promotes melanoma development.2
385323592024SIRT5 promote malignant advancement of chordoma by regulating the desuccinylation of c-myc.1
352787142023LDHA Desuccinylase Sirtuin 5 as A Novel Cancer Metastatic Stimulator in Aggressive Prostate Cancer.16
366178192023SIRT5 reduces the inflammatory response and barrier dysfunction in IL-17A-induced epidermal keratinocytes.4
367177932023Circ-ATL1 silencing reverses the activation effects of SIRT5 on smooth muscle cellular proliferation, migration and contractility in intracranial aneurysm by adsorbing miR-455.3
367364262023The deacylase sirtuin 5 reduces malonylation in nonmitochondrial metabolic pathways in diabetic kidney disease.8
368130742023Role of SIRT5 in cancer. Friend or Foe?4
369801942023Emerging Roles of SIRT5 in Metabolism, Cancer, and SARS-CoV-2 Infection.6
352787142023LDHA Desuccinylase Sirtuin 5 as A Novel Cancer Metastatic Stimulator in Aggressive Prostate Cancer.16
366178192023SIRT5 reduces the inflammatory response and barrier dysfunction in IL-17A-induced epidermal keratinocytes.4
367177932023Circ-ATL1 silencing reverses the activation effects of SIRT5 on smooth muscle cellular proliferation, migration and contractility in intracranial aneurysm by adsorbing miR-455.3

Citation

Dessen P

SIRT5 (sirtuin 5)

Atlas Genet Cytogenet Oncol Haematol. 2013-08-01

Online version: http://atlasgeneticsoncology.org/gene/53478/tumors-explorer/case-report-explorer/case-report-explorer/