HERPUD1 (homocysteine inducible ER protein with ubiquitin like domain 1)

2013-08-01  

Identity

HGNC
HERPUD1
LOCATION
16q13
LOCUSID
9709
ALIAS
HERP,Mif1,SUP
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 9709
MIM: 608070
HGNC: 13744
Ensembl: ENSG00000051108

Variants:

dbSNP: 9709
ClinVar: 9709
TCGA: ENSG00000051108
COSMIC: HERPUD1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000051108ENST00000300302Q15011
ENSG00000051108ENST00000344114Q15011
ENSG00000051108ENST00000379792Q15011
ENSG00000051108ENST00000439977Q15011
ENSG00000051108ENST00000563343H3BP08
ENSG00000051108ENST00000563911H3BQM2
ENSG00000051108ENST00000565966H3BRS4
ENSG00000051108ENST00000568358H3BTA8
ENSG00000051108ENST00000568651H3BV54
ENSG00000051108ENST00000569429H3BTT7

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Protein processing in endoplasmic reticulumKEGGko04141
Protein processing in endoplasmic reticulumKEGGhsa04141
HRD1/SEL1 ERAD complexKEGGhsa_M00403
HRD1/SEL1 ERAD complexKEGGM00403
Metabolism of proteinsREACTOMER-HSA-392499
Unfolded Protein Response (UPR)REACTOMER-HSA-381119
PERK regulates gene expressionREACTOMER-HSA-381042
ATF4 activates genesREACTOMER-HSA-380994

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
362209832023Association of HERPUD1 genetic variant rs2217332 with age-related macular degeneration and polypoidal choroidal vasculopathy in an Indian cohort.0
367468402023Herpud1 deficiency alleviates homocysteine-induced aortic valve calcification.2
362209832023Association of HERPUD1 genetic variant rs2217332 with age-related macular degeneration and polypoidal choroidal vasculopathy in an Indian cohort.0
367468402023Herpud1 deficiency alleviates homocysteine-induced aortic valve calcification.2
365441042022HERPUD1 promotes ovarian cancer cell survival by sustaining autophagy and inhibit apoptosis via PI3K/AKT/mTOR and p38 MAPK signaling pathways.9
365441042022HERPUD1 promotes ovarian cancer cell survival by sustaining autophagy and inhibit apoptosis via PI3K/AKT/mTOR and p38 MAPK signaling pathways.9
343539092021The Brucella effector BspL targets the ER-associated degradation (ERAD) pathway and delays bacterial egress from infected cells.7
343539092021The Brucella effector BspL targets the ER-associated degradation (ERAD) pathway and delays bacterial egress from infected cells.7
324885402020Herpud1 deficiency could reduce amyloid-β40 expression and thereby suppress homocysteine-induced atherosclerosis by blocking the JNK/AP1 pathway.4
324885402020Herpud1 deficiency could reduce amyloid-β40 expression and thereby suppress homocysteine-induced atherosclerosis by blocking the JNK/AP1 pathway.4
292959532018The endoplasmic reticulum-residing chaperone BiP is short-lived and metabolized through N-terminal arginylation.26
298630802018An E3 Ubiquitin Ligase, Synoviolin, Is Involved in the Degradation of Homocysteine-Inducible Endoplasmic Reticulum Protein.3
292959532018The endoplasmic reticulum-residing chaperone BiP is short-lived and metabolized through N-terminal arginylation.26
298630802018An E3 Ubiquitin Ligase, Synoviolin, Is Involved in the Degradation of Homocysteine-Inducible Endoplasmic Reticulum Protein.3
284307892017MiR-9-3p augments apoptosis induced by H2O2 through down regulation of Herpud1 in glioma.21

Citation

Dessen P

HERPUD1 (homocysteine inducible ER protein with ubiquitin like domain 1)

Atlas Genet Cytogenet Oncol Haematol. 2013-08-01

Online version: http://atlasgeneticsoncology.org/gene/53491