PRDM9 (PR/SET domain 9)

2013-11-01  

Identity

HGNC
PRDM9
LOCATION
5p14.2
LOCUSID
56979
ALIAS
KMT8B,MEISETZ,MSBP3,PFM6,ZNF899

Other Information

Locus ID:

NCBI: 56979
MIM: 609760
HGNC: 13994
Ensembl: ENSG00000164256

Variants:

dbSNP: 56979
ClinVar: 56979
TCGA: ENSG00000164256
COSMIC: PRDM9

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000164256ENST00000296682Q9NQV7
ENSG00000164256ENST00000502755D6RD68
ENSG00000164256ENST00000635252A0A0U1RQY2

Expression (GTEx)

0
1
2
3
4
5
6
7
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Lysine degradationKEGGko00310
Lysine degradationKEGGhsa00310
Cell CycleREACTOMER-HSA-1640170
MeiosisREACTOMER-HSA-1500620
Meiotic recombinationREACTOMER-HSA-912446
Chromatin organizationREACTOMER-HSA-4839726
Chromatin modifying enzymesREACTOMER-HSA-3247509
PKMTs methylate histone lysinesREACTOMER-HSA-3214841

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

References

Pubmed IDYearTitleCitations
376086632024FBLN5 was Regulated by PRDM9, and Promoted Senescence and Osteogenic Differentiation of Human Periodontal Ligament Stem Cells.0
376086632024FBLN5 was Regulated by PRDM9, and Promoted Senescence and Osteogenic Differentiation of Human Periodontal Ligament Stem Cells.0
366881882023Association of Single Nucleotide Polymorphisms in the PYGO2 and PRDM9 Genes with Idiopathic Azoospermia in Iranian Infertile Male Patients.0
380037132023Cancer Associated PRDM9: Implications for Linking Genomic Instability and Meiotic Recombination.0
366881882023Association of Single Nucleotide Polymorphisms in the PYGO2 and PRDM9 Genes with Idiopathic Azoospermia in Iranian Infertile Male Patients.0
380037132023Cancer Associated PRDM9: Implications for Linking Genomic Instability and Meiotic Recombination.0
351629972022The KRAB Domain of ZNF10 Guides the Identification of Specific Amino Acids That Transform the Ancestral KRAB-A-Related Domain Present in Human PRDM9 into a Canonical Modern KRAB-A Domain.4
352176072022PRDM9 losses in vertebrates are coupled to those of paralogs ZCWPW1 and ZCWPW2.14
351629972022The KRAB Domain of ZNF10 Guides the Identification of Specific Amino Acids That Transform the Ancestral KRAB-A-Related Domain Present in Human PRDM9 into a Canonical Modern KRAB-A Domain.4
352176072022PRDM9 losses in vertebrates are coupled to those of paralogs ZCWPW1 and ZCWPW2.14
342574192021Pathogenic variants of meiotic double strand break (DSB) formation genes PRDM9 and ANKRD31 in premature ovarian insufficiency.6
342574192021Pathogenic variants of meiotic double strand break (DSB) formation genes PRDM9 and ANKRD31 in premature ovarian insufficiency.6
327445062020ZCWPW1 is recruited to recombination hotspots by PRDM9 and is essential for meiotic double strand break repair.22
327445062020ZCWPW1 is recruited to recombination hotspots by PRDM9 and is essential for meiotic double strand break repair.22
293666062018PRDM9 and Its Role in Genetic Recombination.65

Citation

Dessen P

PRDM9 (PR/SET domain 9)

Atlas Genet Cytogenet Oncol Haematol. 2013-11-01

Online version: http://atlasgeneticsoncology.org/gene/53542