CEP76 (centrosomal protein 76)

2014-01-01  

Identity

HGNC
CEP76
LOCATION
18p11.21
LOCUSID
79959
ALIAS
C18orf9,HsT1705
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 79959
HGNC: 25727
Ensembl: ENSG00000101624

Variants:

dbSNP: 79959
ClinVar: 79959
TCGA: ENSG00000101624
COSMIC: CEP76

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000101624ENST00000262127Q8TAP6
ENSG00000101624ENST00000423709Q8TAP6
ENSG00000101624ENST00000585751K7EP44
ENSG00000101624ENST00000587666K7EIV8
ENSG00000101624ENST00000587929B4DP81
ENSG00000101624ENST00000590143K7EII2
ENSG00000101624ENST00000591034K7EPF5
ENSG00000101624ENST00000593250K7EII2

Expression (GTEx)

0
5
10
15
20
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Organelle biogenesis and maintenanceREACTOMER-HSA-1852241
Cilium AssemblyREACTOMER-HSA-5617833
Anchoring of the basal body to the plasma membraneREACTOMER-HSA-5620912
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
Mitotic G2-G2/M phasesREACTOMER-HSA-453274
G2/M TransitionREACTOMER-HSA-69275
Regulation of PLK1 Activity at G2/M TransitionREACTOMER-HSA-2565942
Centrosome maturationREACTOMER-HSA-380287
Recruitment of mitotic centrosome proteins and complexesREACTOMER-HSA-380270
Loss of proteins required for interphase microtubule organization from the centrosomeREACTOMER-HSA-380284
Loss of Nlp from mitotic centrosomesREACTOMER-HSA-380259
AURKA Activation by TPX2REACTOMER-HSA-8854518

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
328789462020The centriole protein CEP76 negatively regulates PLK1 activity in the cytoplasm for proper mitotic progression.3
328789462020The centriole protein CEP76 negatively regulates PLK1 activity in the cytoplasm for proper mitotic progression.3
270653282016Opposing post-translational modifications regulate Cep76 function to suppress centriole amplification.9
270653282016Opposing post-translational modifications regulate Cep76 function to suppress centriole amplification.9
194603422009Cep76, a centrosomal protein that specifically restrains centriole reduplication.40
194603422009Cep76, a centrosomal protein that specifically restrains centriole reduplication.40

Citation

Dessen P

CEP76 (centrosomal protein 76)

Atlas Genet Cytogenet Oncol Haematol. 2014-01-01

Online version: http://atlasgeneticsoncology.org/gene/53572/js/lib/favicon/tumors-explorer/