NFKBIZ (NFKB inhibitor zeta)

2013-11-01  

Identity

HGNC
NFKBIZ
LOCATION
3q12.3
LOCUSID
64332
ALIAS
IKBZ,INAP,MAIL
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 64332
MIM: 608004
HGNC: 29805
Ensembl: ENSG00000144802

Variants:

dbSNP: 64332
ClinVar: 64332
TCGA: ENSG00000144802
COSMIC: NFKBIZ

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000144802ENST00000326151Q9BYH8
ENSG00000144802ENST00000326172Q9BYH8
ENSG00000144802ENST00000394054Q9BYH8
ENSG00000144802ENST00000461724C9J5G8
ENSG00000144802ENST00000477601H7C5S1
ENSG00000144802ENST00000483180C9JZ23
ENSG00000144802ENST00000491281C9J5I7

Expression (GTEx)

0
10
20
30
40
50
60
70
80
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Transcriptional misregulation in cancerKEGGko05202
Transcriptional misregulation in cancerKEGGhsa05202

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
385815702024NFKBIZ regulates NFκB signaling pathway to mediate tumorigenesis and metastasis of hepatocellular carcinoma by direct interaction with TRIM16.0
389607182024Structural and biochemical analyses of the nuclear IκBζ protein in complex with the NF-κB p50 homodimer.1
385815702024NFKBIZ regulates NFκB signaling pathway to mediate tumorigenesis and metastasis of hepatocellular carcinoma by direct interaction with TRIM16.0
389607182024Structural and biochemical analyses of the nuclear IκBζ protein in complex with the NF-κB p50 homodimer.1
377259832023IκBζ is an essential mediator of immunity to oropharyngeal candidiasis.1
377259832023IκBζ is an essential mediator of immunity to oropharyngeal candidiasis.1
351489992022PFN1 Prevents Psoriasis Pathogenesis through IκBζ Regulation.5
357779902022Genetic variants in the NF-κB signaling pathway (NFKB1, NFKBIA, NFKBIZ) and risk of critical outcome among COVID-19 patients.5
362452912022Emerging role of IκBζ in inflammation: Emphasis on psoriasis.3
351489992022PFN1 Prevents Psoriasis Pathogenesis through IκBζ Regulation.5
357779902022Genetic variants in the NF-κB signaling pathway (NFKB1, NFKBIA, NFKBIZ) and risk of critical outcome among COVID-19 patients.5
362452912022Emerging role of IκBζ in inflammation: Emphasis on psoriasis.3
334910922021IkBζ is a Key Regulator of Tumour Necrosis Factor-a and Interleukin-17A-mediated Induction of Interleukin-36g in Human Keratinocytes.4
339078272021Upregulation of NFKBIZ affects bladder cancer progression via the PTEN/PI3K/Akt signaling pathway.9
334910922021IkBζ is a Key Regulator of Tumour Necrosis Factor-a and Interleukin-17A-mediated Induction of Interleukin-36g in Human Keratinocytes.4

Citation

Dessen P

NFKBIZ (NFKB inhibitor zeta)

Atlas Genet Cytogenet Oncol Haematol. 2013-11-01

Online version: http://atlasgeneticsoncology.org/gene/53613