AOX1 (aldehyde oxidase 1)

2013-11-01  

Identity

HGNC
AOX1
LOCATION
2q33.1
LOCUSID
316
ALIAS
AO,AOH1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 316
MIM: 602841
HGNC: 553
Ensembl: ENSG00000138356

Variants:

dbSNP: 316
ClinVar: 316
TCGA: ENSG00000138356
COSMIC: AOX1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000138356ENST00000260930H7BXF7
ENSG00000138356ENST00000374700Q06278
ENSG00000138356ENST00000439380H7C3Q1
ENSG00000138356ENST00000454629C9J244

Expression (GTEx)

0
50
100
150
200
250
300
350
400
450
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Valine, leucine and isoleucine degradationKEGGko00280
Tyrosine metabolismKEGGko00350
Tryptophan metabolismKEGGko00380
Vitamin B6 metabolismKEGGko00750
Nicotinate and nicotinamide metabolismKEGGko00760
Retinol metabolismKEGGko00830
Drug metabolism - cytochrome P450KEGGko00982
Jak-STAT signaling pathwayKEGGko04630
Valine, leucine and isoleucine degradationKEGGhsa00280
Tyrosine metabolismKEGGhsa00350
Tryptophan metabolismKEGGhsa00380
Vitamin B6 metabolismKEGGhsa00750
Nicotinate and nicotinamide metabolismKEGGhsa00760
Retinol metabolismKEGGhsa00830
Drug metabolism - cytochrome P450KEGGhsa00982
Jak-STAT signaling pathwayKEGGhsa04630
Metabolic pathwaysKEGGhsa01100
MetabolismREACTOMER-HSA-1430728
Metabolism of vitamins and cofactorsREACTOMER-HSA-196854
Metabolism of water-soluble vitamins and cofactorsREACTOMER-HSA-196849
Vitamins B6 activation to pyridoxal phosphateREACTOMER-HSA-964975

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA165958521febuxostatChemicalClinicalAnnotationassociatedPD27798726
PA166114484XK469ChemicalClinicalAnnotationassociatedPK
PA444318GoutDiseaseClinicalAnnotationassociatedPD27798726
PA446116Inflammatory Bowel DiseasesDiseaseClinicalAnnotationassociatedPD19500084
PA448320allopurinolChemicalClinicalAnnotationassociatedPD27798726
PA448515azathioprineChemicalClinicalAnnotationassociatedPD19500084

References

Pubmed IDYearTitleCitations
381995972024Aldehyde oxidase 1 promotes gallbladder carcinogenesis through ROS-mediated activation of the Wnt/β-catenin pathway.0
390343542024Role of AOX1 on RXR signaling regulates osteoblastogenesis in hPDLMSCs.0
381995972024Aldehyde oxidase 1 promotes gallbladder carcinogenesis through ROS-mediated activation of the Wnt/β-catenin pathway.0
390343542024Role of AOX1 on RXR signaling regulates osteoblastogenesis in hPDLMSCs.0
353541502023DNA Methylation-Mediated Lowly Expressed AOX1 Promotes Cell Migration and Invasion of Prostate Cancer.3
378274552023Aldehyde oxidase 1 activity and protein expression in human, rabbit, and pig ocular tissues.0
353541502023DNA Methylation-Mediated Lowly Expressed AOX1 Promotes Cell Migration and Invasion of Prostate Cancer.3
378274552023Aldehyde oxidase 1 activity and protein expression in human, rabbit, and pig ocular tissues.0
313839402020Epigenetic loss of AOX1 expression via EZH2 leads to metabolic deregulations and promotes bladder cancer progression.30
319937602020Population Pharmacokinetics of Sulindac and Genetic Polymorphisms of FMO3 and AOX1 in Women with Preterm Labor.3
324708782020Aldehyde oxidase 1 promoted the occurrence and development of colorectal cancer by up-regulation of expression of CD133.9
313839402020Epigenetic loss of AOX1 expression via EZH2 leads to metabolic deregulations and promotes bladder cancer progression.30
319937602020Population Pharmacokinetics of Sulindac and Genetic Polymorphisms of FMO3 and AOX1 in Women with Preterm Labor.3
324708782020Aldehyde oxidase 1 promoted the occurrence and development of colorectal cancer by up-regulation of expression of CD133.9
309859872019Human aldehyde oxidase (hAOX1): structure determination of the Moco-free form of the natural variant G1269R and biophysical studies of single nucleotide polymorphisms.0

Citation

Dessen P

AOX1 (aldehyde oxidase 1)

Atlas Genet Cytogenet Oncol Haematol. 2013-11-01

Online version: http://atlasgeneticsoncology.org/gene/53623/gene-fusions/js/css/lib/bootstrap.min.css