GLUD1 (glutamate dehydrogenase 1)

2013-12-01  

Identity

HGNC
GLUD1
LOCATION
10q23.2
LOCUSID
2746
ALIAS
GDH,GDH1,GLUD
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 2746
MIM: 138130
HGNC: 4335
Ensembl: ENSG00000148672

Variants:

dbSNP: 2746
ClinVar: 2746
TCGA: ENSG00000148672
COSMIC: GLUD1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000148672ENST00000277865P00367
ENSG00000148672ENST00000277865E9KL48

Expression (GTEx)

0
50
100
150
200
250
300
350
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Arginine biosynthesisKEGGko00220
D-Glutamine and D-glutamate metabolismKEGGko00471
Nitrogen metabolismKEGGko00910
Arginine biosynthesisKEGGhsa00220
D-Glutamine and D-glutamate metabolismKEGGhsa00471
Nitrogen metabolismKEGGhsa00910
Alanine, aspartate and glutamate metabolismKEGGko00250
Alanine, aspartate and glutamate metabolismKEGGhsa00250
Metabolic pathwaysKEGGhsa01100
Proximal tubule bicarbonate reclamationKEGGko04964
Proximal tubule bicarbonate reclamationKEGGhsa04964
Carbon metabolismKEGGhsa01200
Carbon metabolismKEGGko01200
MetabolismREACTOMER-HSA-1430728
Metabolism of amino acids and derivativesREACTOMER-HSA-71291
Amino acid synthesis and interconversion (transamination)REACTOMER-HSA-70614

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
382457632024Bioinformatics analysis identifies GLUD1 as a prognostic indicator for clear cell renal cell carcinoma.0
390528312024Lack of evidence for direct ligand-gated ion channel activity of GluD receptors.0
382457632024Bioinformatics analysis identifies GLUD1 as a prognostic indicator for clear cell renal cell carcinoma.0
390528312024Lack of evidence for direct ligand-gated ion channel activity of GluD receptors.0
366955472023Hyperinsulinism/hyperammonemia syndrome caused by biallelic SLC25A36 mutation.1
370923192023Glutamate dehydrogenase1 supports HIF-1α stability to promote colorectal tumorigenesis under hypoxia.1
366955472023Hyperinsulinism/hyperammonemia syndrome caused by biallelic SLC25A36 mutation.1
370923192023Glutamate dehydrogenase1 supports HIF-1α stability to promote colorectal tumorigenesis under hypoxia.1
355957542022Oncogenic circTICRR suppresses autophagy via binding to HuR protein and stabilizing GLUD1 mRNA in cervical cancer.8
359526312022Mosaic GLUD1 Mutations Associated with Hyperinsulinism Hyperammonemia Syndrome.1
355957542022Oncogenic circTICRR suppresses autophagy via binding to HuR protein and stabilizing GLUD1 mRNA in cervical cancer.8
359526312022Mosaic GLUD1 Mutations Associated with Hyperinsulinism Hyperammonemia Syndrome.1
340721542021Mapping the Intramolecular Communications among Different Glutamate Dehydrogenase States Using Molecular Dynamics.1
342694832021Cytosolic GDH1 degradation restricts protein synthesis to sustain tumor cell survival following amino acid deprivation.12
340721542021Mapping the Intramolecular Communications among Different Glutamate Dehydrogenase States Using Molecular Dynamics.1

Citation

Dessen P

GLUD1 (glutamate dehydrogenase 1)

Atlas Genet Cytogenet Oncol Haematol. 2013-12-01

Online version: http://atlasgeneticsoncology.org/gene/53627