AJUBA (ajuba LIM protein)

2014-01-01  

Identity

HGNC
LOCATION
14q11.2
LOCUSID
ALIAS
JUB
FUSION GENES

Other Information

Locus ID:

NCBI: 84962
MIM: 609066
HGNC: 20250
Ensembl: ENSG00000129474

Variants:

dbSNP: 84962
ClinVar: 84962
TCGA: ENSG00000129474
COSMIC: AJUBA

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000129474ENST00000262713Q96IF1
ENSG00000129474ENST00000361265Q96IF1
ENSG00000129474ENST00000397388Q96IF1
ENSG00000129474ENST00000553592G3V481
ENSG00000129474ENST00000553736H0YJL9
ENSG00000129474ENST00000553911G3V5F5
ENSG00000129474ENST00000556731G3V481

Expression (GTEx)

0
5
10
15
20
25
30
35

Pathways

PathwaySourceExternal ID
Hippo signaling pathwayKEGGhsa04390
Hippo signaling pathwayKEGGko04390
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
Mitotic G2-G2/M phasesREACTOMER-HSA-453274
G2/M TransitionREACTOMER-HSA-69275
Regulation of PLK1 Activity at G2/M TransitionREACTOMER-HSA-2565942
Developmental BiologyREACTOMER-HSA-1266738
Cellular responses to stressREACTOMER-HSA-2262752
Cellular response to hypoxiaREACTOMER-HSA-2262749
Regulation of Hypoxia-inducible Factor (HIF) by oxygenREACTOMER-HSA-1234174
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor AlphaREACTOMER-HSA-1234176
Activation of HOX genes during differentiationREACTOMER-HSA-5619507
Activation of anterior HOX genes in hindbrain development during early embryogenesisREACTOMER-HSA-5617472
Hippo signaling pathway -multiple speciesKEGGko04392
Hippo signaling pathway -multiple speciesKEGGhsa04392

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
369317002023LIM domain-containing protein Ajuba inhibits chemotherapy-induced apoptosis by negatively regulating p53 stability in colorectal cancer cells.0
369317002023LIM domain-containing protein Ajuba inhibits chemotherapy-induced apoptosis by negatively regulating p53 stability in colorectal cancer cells.0
345184862022miR-433-3p Targets AJUBA to Inhibit Malignant Progression of Glioma.3
351784462022Ajuba Overexpression Promotes Breast Cancer Chemoresistance and Glucose Uptake through TAZ-GLUT3/Survivin Pathway.1
345184862022miR-433-3p Targets AJUBA to Inhibit Malignant Progression of Glioma.3
351784462022Ajuba Overexpression Promotes Breast Cancer Chemoresistance and Glucose Uptake through TAZ-GLUT3/Survivin Pathway.1
341737182021Ajuba transactivates N-cadherin expression in colorectal cancer cells through interaction with Twist.6
347062342021Mitophagy antagonism by ZIKV reveals Ajuba as a regulator of PINK1 signaling, PKR-dependent inflammation, and viral invasion of tissues.18
341737182021Ajuba transactivates N-cadherin expression in colorectal cancer cells through interaction with Twist.6
347062342021Mitophagy antagonism by ZIKV reveals Ajuba as a regulator of PINK1 signaling, PKR-dependent inflammation, and viral invasion of tissues.18
317403852020Ajuba: An emerging signal transducer in oncogenesis.12
326815812020Hsa_circ_0128846 promotes tumorigenesis of colorectal cancer by sponging hsa-miR-1184 and releasing AJUBA and inactivating Hippo/YAP signalling.23
328021792020Super-enhancer-driven AJUBA is activated by TCF4 and involved in epithelial-mesenchymal transition in the progression of Hepatocellular Carcinoma.23
336408882020Knockout of Ajuba Attenuates the Growth and Migration of Hepatocellular Carcinoma Cells.1
317403852020Ajuba: An emerging signal transducer in oncogenesis.12

Citation

Dessen P

AJUBA (ajuba LIM protein)

Atlas Genet Cytogenet Oncol Haematol. 2014-01-01

Online version: http://atlasgeneticsoncology.org/gene/53655/gene-fusions-explorer/favicon/img/logo-atlas-4.svg