DNER (delta/notch like EGF repeat containing)

2014-01-01  

Identity

HGNC
DNER
LOCATION
2q36.3
LOCUSID
92737
ALIAS
UNQ26,bet
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 92737
MIM: 607299
HGNC: 24456
Ensembl: ENSG00000187957

Variants:

dbSNP: 92737
ClinVar: 92737
TCGA: ENSG00000187957
COSMIC: DNER

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000187957ENST00000341772Q8NFT8

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by NOTCHREACTOMER-HSA-157118
Signaling by NOTCH1REACTOMER-HSA-1980143
Activated NOTCH1 Transmits Signal to the NucleusREACTOMER-HSA-2122948

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
382160822024BET protein-dependent E2F pathway activity confers bell-shaped type resistance to tankyrase inhibitors in APC-mutated colorectal cancer.0
385888302024Co-inhibition of BET and NAE enhances BIM-dependent apoptosis with augmented cancer therapeutic efficacy.0
382160822024BET protein-dependent E2F pathway activity confers bell-shaped type resistance to tankyrase inhibitors in APC-mutated colorectal cancer.0
385888302024Co-inhibition of BET and NAE enhances BIM-dependent apoptosis with augmented cancer therapeutic efficacy.0
368835642023mTOR inhibition overcomes RSK3-mediated resistance to BET inhibitors in small cell lung cancer.6
372230282023Role of Delta/Notch-like EGF-related receptor in blood glucose homeostasis.1
373732282023Delta/Notch-like Epidermal Growth Factor-Related Receptor (DNER), a Potential Prognostic Marker of Gastric Cancer Regulates Cell Survival and Cell Cycle Progression.1
368835642023mTOR inhibition overcomes RSK3-mediated resistance to BET inhibitors in small cell lung cancer.6
372230282023Role of Delta/Notch-like EGF-related receptor in blood glucose homeostasis.1
373732282023Delta/Notch-like Epidermal Growth Factor-Related Receptor (DNER), a Potential Prognostic Marker of Gastric Cancer Regulates Cell Survival and Cell Cycle Progression.1
345207472022Development of an intracellular quantitative assay to measure compound binding kinetics.1
346888422022Repressing MYC by targeting BET synergizes with selective inhibition of PI3Kα against B cell lymphoma.6
345207472022Development of an intracellular quantitative assay to measure compound binding kinetics.1
346888422022Repressing MYC by targeting BET synergizes with selective inhibition of PI3Kα against B cell lymphoma.6
333565542021Epigenetic targeting of Waldenström macroglobulinemia cells with BET inhibitors synergizes with BCL2 or histone deacetylase inhibition.4

Citation

Dessen P

DNER (delta/notch like EGF repeat containing)

Atlas Genet Cytogenet Oncol Haematol. 2014-01-01

Online version: http://atlasgeneticsoncology.org/gene/53665/meetings/js/lib/deep-insight-explorer/