DNER (delta/notch like EGF repeat containing)

2014-01-01  

Identity

HGNC
LOCATION
2q36.3
LOCUSID
ALIAS
UNQ26,bet
FUSION GENES

Other Information

Locus ID:

NCBI: 92737
MIM: 607299
HGNC: 24456
Ensembl: ENSG00000187957

Variants:

dbSNP: 92737
ClinVar: 92737
TCGA: ENSG00000187957
COSMIC: DNER

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000187957ENST00000341772Q8NFT8

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by NOTCHREACTOMER-HSA-157118
Signaling by NOTCH1REACTOMER-HSA-1980143
Activated NOTCH1 Transmits Signal to the NucleusREACTOMER-HSA-2122948

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
382160822024BET protein-dependent E2F pathway activity confers bell-shaped type resistance to tankyrase inhibitors in APC-mutated colorectal cancer.0
385888302024Co-inhibition of BET and NAE enhances BIM-dependent apoptosis with augmented cancer therapeutic efficacy.0
382160822024BET protein-dependent E2F pathway activity confers bell-shaped type resistance to tankyrase inhibitors in APC-mutated colorectal cancer.0
385888302024Co-inhibition of BET and NAE enhances BIM-dependent apoptosis with augmented cancer therapeutic efficacy.0
368835642023mTOR inhibition overcomes RSK3-mediated resistance to BET inhibitors in small cell lung cancer.6
372230282023Role of Delta/Notch-like EGF-related receptor in blood glucose homeostasis.1
373732282023Delta/Notch-like Epidermal Growth Factor-Related Receptor (DNER), a Potential Prognostic Marker of Gastric Cancer Regulates Cell Survival and Cell Cycle Progression.1
368835642023mTOR inhibition overcomes RSK3-mediated resistance to BET inhibitors in small cell lung cancer.6
372230282023Role of Delta/Notch-like EGF-related receptor in blood glucose homeostasis.1
373732282023Delta/Notch-like Epidermal Growth Factor-Related Receptor (DNER), a Potential Prognostic Marker of Gastric Cancer Regulates Cell Survival and Cell Cycle Progression.1
345207472022Development of an intracellular quantitative assay to measure compound binding kinetics.1
346888422022Repressing MYC by targeting BET synergizes with selective inhibition of PI3Kα against B cell lymphoma.6
345207472022Development of an intracellular quantitative assay to measure compound binding kinetics.1
346888422022Repressing MYC by targeting BET synergizes with selective inhibition of PI3Kα against B cell lymphoma.6
333565542021Epigenetic targeting of Waldenström macroglobulinemia cells with BET inhibitors synergizes with BCL2 or histone deacetylase inhibition.4

Citation

Dessen P

DNER (delta/notch like EGF repeat containing)

Atlas Genet Cytogenet Oncol Haematol. 2014-01-01

Online version: http://atlasgeneticsoncology.org/gene/53665/meetings/js/lib/tumors-explorer/