CLEC4M (C-type lectin domain family 4 member M)

2014-01-01  

Identity

HGNC
CLEC4M
LOCATION
19p13.2
LOCUSID
10332
ALIAS
CD209L,CD299,DC-SIGN2,DC-SIGNR,DCSIGNR,HP10347,L-SIGN,LSIGN

Other Information

Locus ID:

NCBI: 10332
MIM: 605872
HGNC: 13523
Ensembl: ENSG00000104938

Variants:

dbSNP: 10332
ClinVar: 10332
TCGA: ENSG00000104938
COSMIC: CLEC4M

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000104938ENST00000248228Q9H2X3
ENSG00000104938ENST00000327325Q9H2X3
ENSG00000104938ENST00000334806H7BXU4
ENSG00000104938ENST00000359059Q9H2X3
ENSG00000104938ENST00000394122E7ENS9
ENSG00000104938ENST00000595496Q9H2X3
ENSG00000104938ENST00000595751M0QZ42
ENSG00000104938ENST00000596363Q9H2X3
ENSG00000104938ENST00000596707M0QYX2
ENSG00000104938ENST00000597522Q9H2X3

Expression (GTEx)

0
5
10
15
20
25
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
PhagosomeKEGGko04145
PhagosomeKEGGhsa04145
MeaslesKEGGko05162
MeaslesKEGGhsa05162
TuberculosisKEGGko05152
TuberculosisKEGGhsa05152

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
338805372021ACE2, TMPRSS2, and L-SIGN Expression in Placentae From HIV-Positive Pregnancies Exposed to Antiretroviral Therapy-Implications for SARS-CoV-2 Placental Infection.1
338805372021ACE2, TMPRSS2, and L-SIGN Expression in Placentae From HIV-Positive Pregnancies Exposed to Antiretroviral Therapy-Implications for SARS-CoV-2 Placental Infection.1
327052122020CLEC4M overexpression inhibits progression and is associated with a favorable prognosis in hepatocellular carcinoma.4
327052122020CLEC4M overexpression inhibits progression and is associated with a favorable prognosis in hepatocellular carcinoma.4
307408572019The endothelial lectin clearance receptor CLEC4M binds and internalizes factor VIII in a VWF-dependent and independent manner.22
307408572019The endothelial lectin clearance receptor CLEC4M binds and internalizes factor VIII in a VWF-dependent and independent manner.22
293899442018Genetic variation in the C-type lectin receptor CLEC4M in type 1 von Willebrand Disease patients.3
293899442018Genetic variation in the C-type lectin receptor CLEC4M in type 1 von Willebrand Disease patients.3
278598592017Oligomerization domains in the glycan-binding receptors DC-SIGN and DC-SIGNR: Sequence variation and stability differences.6
284038832017DC - SIGNR by influencing the lncRNA HNRNPKP2 upregulates the expression of CXCR4 in gastric cancer liver metastasis.23
278598592017Oligomerization domains in the glycan-binding receptors DC-SIGN and DC-SIGNR: Sequence variation and stability differences.6
284038832017DC - SIGNR by influencing the lncRNA HNRNPKP2 upregulates the expression of CXCR4 in gastric cancer liver metastasis.23
273094782016Association of DC-SIGN and DC-SIGNR Repeat Regions with Susceptibility to Pulmonary Tuberculosis in Zahedan, Southeastern Iran.0
273345792016DC-SIGN and L-SIGN Are Attachment Factors That Promote Infection of Target Cells by Human Metapneumovirus in the Presence or Absence of Cellular Glycosaminoglycans.6
273094782016Association of DC-SIGN and DC-SIGNR Repeat Regions with Susceptibility to Pulmonary Tuberculosis in Zahedan, Southeastern Iran.0

Citation

Dessen P

CLEC4M (C-type lectin domain family 4 member M)

Atlas Genet Cytogenet Oncol Haematol. 2014-01-01

Online version: http://atlasgeneticsoncology.org/gene/53673