SIRT4 (sirtuin 4)

2014-01-01  

Identity

HGNC
SIRT4
LOCATION
12q24.31
LOCUSID
23409
ALIAS
SIR2L4

Other Information

Locus ID:

NCBI: 23409
MIM: 604482
HGNC: 14932
Ensembl: ENSG00000089163

Variants:

dbSNP: 23409
ClinVar: 23409
TCGA: ENSG00000089163
COSMIC: SIRT4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000089163ENST00000202967Q9Y6E7
ENSG00000089163ENST00000536460F5H4X9

Expression (GTEx)

0
5
10
15
20
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
384993272024SIRT4 as a novel interactor and candidate suppressor of C-RAF kinase in MAPK signaling.0
385482462024SIRT3 and SIRT4 double-genes remodeled the mitochondrial network to induce hepatocellular carcinoma cell line differentiation and suppress malignant phenotypes.1
385868752024SIRT4 promotes neuronal apoptosis in models of Alzheimer's disease via the STAT2-SIRT4-mTOR pathway.1
384993272024SIRT4 as a novel interactor and candidate suppressor of C-RAF kinase in MAPK signaling.0
385482462024SIRT3 and SIRT4 double-genes remodeled the mitochondrial network to induce hepatocellular carcinoma cell line differentiation and suppress malignant phenotypes.1
385868752024SIRT4 promotes neuronal apoptosis in models of Alzheimer's disease via the STAT2-SIRT4-mTOR pathway.1
362091692023Sirtuin 4 activates autophagy and inhibits tumorigenesis by upregulating the p53 signaling pathway.12
370676872023SIRT4 in ageing.3
371467132023Sirtuin4 impacts mitochondrial homeostasis in pancreatic cancer cells by reducing the stability of AlkB homolog 1 via deacetylation of the HRD1-SEL1L complex.3
371783832023The Regulation of GLT-1 Degradation Pathway by SIRT4.0
375416332023SIRT4 protects against intestinal fibrosis by facilitating GLS1 degradation.3
378586142023SIRT4 is a regulator of human skeletal muscle fatty acid metabolism influencing inner and outer mitochondrial membrane-mediated fusion.3
362091692023Sirtuin 4 activates autophagy and inhibits tumorigenesis by upregulating the p53 signaling pathway.12
370676872023SIRT4 in ageing.3
371467132023Sirtuin4 impacts mitochondrial homeostasis in pancreatic cancer cells by reducing the stability of AlkB homolog 1 via deacetylation of the HRD1-SEL1L complex.3

Citation

Dessen P

SIRT4 (sirtuin 4)

Atlas Genet Cytogenet Oncol Haematol. 2014-01-01

Online version: http://atlasgeneticsoncology.org/gene/53767