FAM107 members contain an N-terminal domain of unknown function (DUF1151) that is conserved across species. Mammals have two genes, FAM107A and FAM107B, which expressions are strong in neural cells, whereas their expressions are mostly down-regulated in cancer cells. Both proteins appear to alter cytoskeleton rearrangements and are involved in cell migration and invasion. The molecular mechanisms underlying the diverse biological functions of FAM107 remain unclear, while it shows functional similarity with heat-shock proteins (HSPs) as well as reactions to cellular stress.
NCBI: 83641 HGNC: 23726 Ensembl: ENSG00000065809
dbSNP: 83641 ClinVar: 83641 TCGA: ENSG00000065809 COSMIC: FAM107B
Hideo Nakajima ; Keita Koizumi
FAM107B (family with sequence similarity 107, member B)
Atlas Genet Cytogenet Oncol Haematol. 2015-01-01
Online version: http://atlasgeneticsoncology.org/gene/53778/js/favicon/haematological-explorer/