MORC3 (MORC family CW-type zinc finger 3)

2014-01-01  

Identity

HGNC
MORC3
LOCATION
21q22.12
LOCUSID
23515
ALIAS
NXP2,ZCW5,ZCWCC3
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 23515
MIM: 610078
HGNC: 23572
Ensembl: ENSG00000159256

Variants:

dbSNP: 23515
ClinVar: 23515
TCGA: ENSG00000159256
COSMIC: MORC3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000159256ENST00000400485Q14149
ENSG00000159256ENST00000546482H0YHQ4
ENSG00000159256ENST00000549948H0YHQ4
ENSG00000159256ENST00000551788H0YHQ4
ENSG00000159256ENST00000552581H0YIR5

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
380096112023MORC3 represses the HCMV major immediate early promoter in myeloid cells in the absence of PML nuclear bodies.1
380096112023MORC3 represses the HCMV major immediate early promoter in myeloid cells in the absence of PML nuclear bodies.1
350261362022En garde! The duel functions of MORC3.0
358791012022MORC3 restricts human cytomegalovirus infection by suppressing the major immediate-early promoter activity.3
350261362022En garde! The duel functions of MORC3.0
358791012022MORC3 restricts human cytomegalovirus infection by suppressing the major immediate-early promoter activity.3
346500472021Morc3 silences endogenous retroviruses by enabling Daxx-mediated histone H3.3 incorporation.23
347593142021Self-guarding of MORC3 enables virulence factor-triggered immunity.21
346500472021Morc3 silences endogenous retroviruses by enabling Daxx-mediated histone H3.3 incorporation.23
347593142021Self-guarding of MORC3 enables virulence factor-triggered immunity.21
308505482019Mechanism for autoinhibition and activation of the MORC3 ATPase.18
310065862019MORC3 Is a Target of the Influenza A Viral Protein NS1.11
308505482019Mechanism for autoinhibition and activation of the MORC3 ATPase.18
310065862019MORC3 Is a Target of the Influenza A Viral Protein NS1.11
281294902017Cutaneous and Systemic Findings Associated With Nuclear Matrix Protein 2 Antibodies in Adult Dermatomyositis Patients.32

Citation

Dessen P

MORC3 (MORC family CW-type zinc finger 3)

Atlas Genet Cytogenet Oncol Haematol. 2014-01-01

Online version: http://atlasgeneticsoncology.org/gene/53782