ALX1 (ALX homeobox 1)

ALX1 (ALX homeobox 1)

2014-02-01 Affiliation

Identity

HGNC

LOCATION

12q21.31

LOCUSID

ALIAS

CART1,FND3,HEL23

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 8092
MIM: 601527
HGNC: 1494
Ensembl: ENSG00000180318

Variants:

dbSNP: 8092
ClinVar: 8092
TCGA: ENSG00000180318
COSMIC: ALX1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000180318	ENST00000316824	Q15699
ENSG00000180318	ENST00000316824	V9HWA7

Expression (GTEx)

0

1

2

3

4

5

6

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
34104082	2021	Promoter Methylation-mediated Silencing of the MiR-192-5p Promotes Endometrial Cancer Progression by Targeting ALX1.	1
34104082	2021	Promoter Methylation-mediated Silencing of the MiR-192-5p Promotes Endometrial Cancer Progression by Targeting ALX1.	1
30773258	2019	Knockdown of aristaless-like homeobox1 inhibits epithelial-mesenchymal transition through Wnt/β-catenin signaling pathway in melanoma cells.	1
30773258	2019	Knockdown of aristaless-like homeobox1 inhibits epithelial-mesenchymal transition through Wnt/β-catenin signaling pathway in melanoma cells.	1
29936472	2018	Novel Potential Biomarkers for Opisthorchis viverrini Infection and Associated Cholangiocarcinoma.	6
29936472	2018	Novel Potential Biomarkers for Opisthorchis viverrini Infection and Associated Cholangiocarcinoma.	6
27324866	2017	Exome sequencing revealed a novel splice site variant in the ALX1 gene underlying frontonasal dysplasia.	5
27324866	2017	Exome sequencing revealed a novel splice site variant in the ALX1 gene underlying frontonasal dysplasia.	5
27053613	2016	[Knockdown of CART1 induces S phase arrest and inhibits invasion and migration of MDA-MB-231 breast cancer cells].	0
27053613	2016	[Knockdown of CART1 induces S phase arrest and inhibits invasion and migration of MDA-MB-231 breast cancer cells].	0
25736924	2015	Depletion of ALX1 causes inhibition of migration and induction of apoptosis in human osteosarcoma.	5
26722397	2015	ALX1 promotes migration and invasion of lung cancer cells through increasing snail expression.	6
25736924	2015	Depletion of ALX1 causes inhibition of migration and induction of apoptosis in human osteosarcoma.	5
26722397	2015	ALX1 promotes migration and invasion of lung cancer cells through increasing snail expression.	6
23288509	2013	ALX1 induces snail expression to promote epithelial-to-mesenchymal transition and invasion of ovarian cancer cells.	33

Citation

Dessen P

ALX1 (ALX homeobox 1)

Atlas Genet Cytogenet Oncol Haematol. 2014-02-01

Online version: http://atlasgeneticsoncology.org/gene/53788/img/meetings/cancer-prone-explorer/js/lib/popper.js