ATG101 (autophagy related 101)

2014-02-01  

Identity

HGNC
ATG101
LOCATION
12q13.13
LOCUSID
60673
ALIAS
C12orf44

Other Information

Locus ID:

NCBI: 60673
MIM: 615089
HGNC: 25679
Ensembl: ENSG00000123395

Variants:

dbSNP: 60673
ClinVar: 60673
TCGA: ENSG00000123395
COSMIC: ATG101

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000123395ENST00000336854Q9BSB4
ENSG00000123395ENST00000336854A0A024R128
ENSG00000123395ENST00000548915F8VVA0
ENSG00000123395ENST00000550604H3BMZ4
ENSG00000123395ENST00000553049F8VQD9

Expression (GTEx)

0
5
10
15
20
25
30
35
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Autophagy - animalKEGGko04140
Autophagy - animalKEGGhsa04140
Cellular responses to stressREACTOMER-HSA-2262752
MacroautophagyREACTOMER-HSA-1632852
Longevity regulating pathwayKEGGhsa04211
Autophagy - otherKEGGko04136
Autophagy - otherKEGGhsa04136

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
373947992024Metamorphosis by ATG13 and ATG101 in human autophagy initiation.0
375677702024The role of the HORMA domain proteins ATG13 and ATG101 in initiating autophagosome biogenesis.0
373947992024Metamorphosis by ATG13 and ATG101 in human autophagy initiation.0
375677702024The role of the HORMA domain proteins ATG13 and ATG101 in initiating autophagosome biogenesis.0
363027992022ATG101-related signature predicts prognosis and therapeutic option in hepatocellular carcinoma.0
363027992022ATG101-related signature predicts prognosis and therapeutic option in hepatocellular carcinoma.0
345020892021ATG101 Degradation by HUWE1-Mediated Ubiquitination Impairs Autophagy and Reduces Survival in Cancer Cells.7
345020892021ATG101 Degradation by HUWE1-Mediated Ubiquitination Impairs Autophagy and Reduces Survival in Cancer Cells.7
300817502018The C-terminal region of ATG101 bridges ULK1 and PtdIns3K complex in autophagy initiation.27
300817502018The C-terminal region of ATG101 bridges ULK1 and PtdIns3K complex in autophagy initiation.27
262999442015Structure of the Human Atg13-Atg101 HORMA Heterodimer: an Interaction Hub within the ULK1 Complex.42
262999442015Structure of the Human Atg13-Atg101 HORMA Heterodimer: an Interaction Hub within the ULK1 Complex.42
236408972013Lacritin rescues stressed epithelia via rapid forkhead box O3 (FOXO3)-associated autophagy that restores metabolism.30
236408972013Lacritin rescues stressed epithelia via rapid forkhead box O3 (FOXO3)-associated autophagy that restores metabolism.30
192872112009A novel, human Atg13 binding protein, Atg101, interacts with ULK1 and is essential for macroautophagy.210

Citation

Dessen P

ATG101 (autophagy related 101)

Atlas Genet Cytogenet Oncol Haematol. 2014-02-01

Online version: http://atlasgeneticsoncology.org/gene/53809/cancer-prone-explorer/gene-fusions-explorer/css/template-card.css