ATG101 (autophagy related 101)

2014-02-01  

Identity

HGNC
LOCATION
12q13.13
LOCUSID
ALIAS
C12orf44

Other Information

Locus ID:

NCBI: 60673
MIM: 615089
HGNC: 25679
Ensembl: ENSG00000123395

Variants:

dbSNP: 60673
ClinVar: 60673
TCGA: ENSG00000123395
COSMIC: ATG101

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000123395ENST00000336854Q9BSB4
ENSG00000123395ENST00000336854A0A024R128
ENSG00000123395ENST00000548915F8VVA0
ENSG00000123395ENST00000550604H3BMZ4
ENSG00000123395ENST00000553049F8VQD9

Expression (GTEx)

0
5
10
15
20
25
30
35

Pathways

PathwaySourceExternal ID
Autophagy - animalKEGGko04140
Autophagy - animalKEGGhsa04140
Cellular responses to stressREACTOMER-HSA-2262752
MacroautophagyREACTOMER-HSA-1632852
Longevity regulating pathwayKEGGhsa04211
Autophagy - otherKEGGko04136
Autophagy - otherKEGGhsa04136

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
373947992024Metamorphosis by ATG13 and ATG101 in human autophagy initiation.0
375677702024The role of the HORMA domain proteins ATG13 and ATG101 in initiating autophagosome biogenesis.0
373947992024Metamorphosis by ATG13 and ATG101 in human autophagy initiation.0
375677702024The role of the HORMA domain proteins ATG13 and ATG101 in initiating autophagosome biogenesis.0
363027992022ATG101-related signature predicts prognosis and therapeutic option in hepatocellular carcinoma.0
363027992022ATG101-related signature predicts prognosis and therapeutic option in hepatocellular carcinoma.0
345020892021ATG101 Degradation by HUWE1-Mediated Ubiquitination Impairs Autophagy and Reduces Survival in Cancer Cells.7
345020892021ATG101 Degradation by HUWE1-Mediated Ubiquitination Impairs Autophagy and Reduces Survival in Cancer Cells.7
300817502018The C-terminal region of ATG101 bridges ULK1 and PtdIns3K complex in autophagy initiation.27
300817502018The C-terminal region of ATG101 bridges ULK1 and PtdIns3K complex in autophagy initiation.27
262999442015Structure of the Human Atg13-Atg101 HORMA Heterodimer: an Interaction Hub within the ULK1 Complex.42
262999442015Structure of the Human Atg13-Atg101 HORMA Heterodimer: an Interaction Hub within the ULK1 Complex.42
236408972013Lacritin rescues stressed epithelia via rapid forkhead box O3 (FOXO3)-associated autophagy that restores metabolism.30
236408972013Lacritin rescues stressed epithelia via rapid forkhead box O3 (FOXO3)-associated autophagy that restores metabolism.30
192872112009A novel, human Atg13 binding protein, Atg101, interacts with ULK1 and is essential for macroautophagy.210

Citation

Dessen P

ATG101 (autophagy related 101)

Atlas Genet Cytogenet Oncol Haematol. 2014-02-01

Online version: http://atlasgeneticsoncology.org/gene/53809/css/js/teaching-explorer/