PRELP (proline and arginine rich end leucine rich repeat protein)

2014-02-01  

Identity

HGNC
LOCATION
1q32.1
LOCUSID
ALIAS
MST161,MSTP161,SLRR2A
FUSION GENES

Other Information

Locus ID:

NCBI: 5549
MIM: 601914
HGNC: 9357
Ensembl: ENSG00000188783

Variants:

dbSNP: 5549
ClinVar: 5549
TCGA: ENSG00000188783
COSMIC: PRELP

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000188783ENST00000343110P51888

Expression (GTEx)

0
500
1000
1500

Pathways

PathwaySourceExternal ID
DiseaseREACTOMER-HSA-1643685
Diseases of glycosylationREACTOMER-HSA-3781865
Diseases associated with glycosaminoglycan metabolismREACTOMER-HSA-3560782
Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)REACTOMER-HSA-3656244
Defective CHST6 causes MCDC1REACTOMER-HSA-3656225
MetabolismREACTOMER-HSA-1430728
Metabolism of carbohydratesREACTOMER-HSA-71387
Glycosaminoglycan metabolismREACTOMER-HSA-1630316
Keratan sulfate/keratin metabolismREACTOMER-HSA-1638074
Keratan sulfate biosynthesisREACTOMER-HSA-2022854
Keratan sulfate degradationREACTOMER-HSA-2022857
Defective ST3GAL3 causes MCT12 and EIEE15REACTOMER-HSA-3656243

References

Pubmed IDYearTitleCitations
377306062023Correlation of the tumor escape phenotype with loss of PRELP expression in melanoma.1
377306062023Correlation of the tumor escape phenotype with loss of PRELP expression in melanoma.1
363712272022Repression of the PRELP gene is relieved by histone deacetylase inhibitors through acetylation of histone H2B lysine 5 in bladder cancer.3
363712272022Repression of the PRELP gene is relieved by histone deacetylase inhibitors through acetylation of histone H2B lysine 5 in bladder cancer.3
334289362021Proteomic identification and validation of novel interactions of the putative tumor suppressor PRELP with membrane proteins including IGFI-R and p75NTR.7
334289362021Proteomic identification and validation of novel interactions of the putative tumor suppressor PRELP with membrane proteins including IGFI-R and p75NTR.7
327822512020A novel biomarker of MMP-cleaved prolargin is elevated in patients with psoriatic arthritis.7
327822512020A novel biomarker of MMP-cleaved prolargin is elevated in patients with psoriatic arthritis.7
294024562018Identification of prolargin expression in articular cartilage and its significance in rheumatoid arthritis pathology.3
294024562018Identification of prolargin expression in articular cartilage and its significance in rheumatoid arthritis pathology.3
281487312017PRELP Enhances Host Innate Immunity against the Respiratory Tract Pathogen Moraxella catarrhalis.6
286789152017Increased expression of ID2, PRELP and SMOC2 genes in patients with endometriosis.3
281487312017PRELP Enhances Host Innate Immunity against the Respiratory Tract Pathogen Moraxella catarrhalis.6
286789152017Increased expression of ID2, PRELP and SMOC2 genes in patients with endometriosis.3
269200262016The leucine-rich repeat protein PRELP binds fibroblast cell-surface proteoglycans and enhances focal adhesion formation.8

Citation

Dessen P

PRELP (proline and arginine rich end leucine rich repeat protein)

Atlas Genet Cytogenet Oncol Haematol. 2014-02-01

Online version: http://atlasgeneticsoncology.org/gene/53811/css/lib/teaching-explorer/