PRELP (proline and arginine rich end leucine rich repeat protein)

2014-02-01 Affiliation

Identity

HGNC

PRELP

LOCATION

1q32.1

LOCUSID

5549

ALIAS

MST161,MSTP161,SLRR2A

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 5549
MIM: 601914
HGNC: 9357
Ensembl: ENSG00000188783

Variants:

dbSNP: 5549
ClinVar: 5549
TCGA: ENSG00000188783
COSMIC: PRELP

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000188783	ENST00000343110	P51888

Expression (GTEx)

500

1000

1500

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Disease	REACTOME	R-HSA-1643685
Diseases of glycosylation	REACTOME	R-HSA-3781865
Diseases associated with glycosaminoglycan metabolism	REACTOME	R-HSA-3560782
Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)	REACTOME	R-HSA-3656244
Defective CHST6 causes MCDC1	REACTOME	R-HSA-3656225
Metabolism	REACTOME	R-HSA-1430728
Metabolism of carbohydrates	REACTOME	R-HSA-71387
Glycosaminoglycan metabolism	REACTOME	R-HSA-1630316
Keratan sulfate/keratin metabolism	REACTOME	R-HSA-1638074
Keratan sulfate biosynthesis	REACTOME	R-HSA-2022854
Keratan sulfate degradation	REACTOME	R-HSA-2022857
Defective ST3GAL3 causes MCT12 and EIEE15	REACTOME	R-HSA-3656243

References

Pubmed ID	Year	Title	Citations
37730606	2023	Correlation of the tumor escape phenotype with loss of PRELP expression in melanoma.	1
37730606	2023	Correlation of the tumor escape phenotype with loss of PRELP expression in melanoma.	1
36371227	2022	Repression of the PRELP gene is relieved by histone deacetylase inhibitors through acetylation of histone H2B lysine 5 in bladder cancer.	3
36371227	2022	Repression of the PRELP gene is relieved by histone deacetylase inhibitors through acetylation of histone H2B lysine 5 in bladder cancer.	3
33428936	2021	Proteomic identification and validation of novel interactions of the putative tumor suppressor PRELP with membrane proteins including IGFI-R and p75NTR.	7
33428936	2021	Proteomic identification and validation of novel interactions of the putative tumor suppressor PRELP with membrane proteins including IGFI-R and p75NTR.	7
32782251	2020	A novel biomarker of MMP-cleaved prolargin is elevated in patients with psoriatic arthritis.	7
32782251	2020	A novel biomarker of MMP-cleaved prolargin is elevated in patients with psoriatic arthritis.	7
29402456	2018	Identification of prolargin expression in articular cartilage and its significance in rheumatoid arthritis pathology.	3
29402456	2018	Identification of prolargin expression in articular cartilage and its significance in rheumatoid arthritis pathology.	3
28148731	2017	PRELP Enhances Host Innate Immunity against the Respiratory Tract Pathogen Moraxella catarrhalis.	6
28678915	2017	Increased expression of ID2, PRELP and SMOC2 genes in patients with endometriosis.	3
28148731	2017	PRELP Enhances Host Innate Immunity against the Respiratory Tract Pathogen Moraxella catarrhalis.	6
28678915	2017	Increased expression of ID2, PRELP and SMOC2 genes in patients with endometriosis.	3
26920026	2016	The leucine-rich repeat protein PRELP binds fibroblast cell-surface proteoglycans and enhances focal adhesion formation.	8

Citation

Dessen P

PRELP (proline and arginine rich end leucine rich repeat protein)

Atlas Genet Cytogenet Oncol Haematol. 2014-02-01

Online version: http://atlasgeneticsoncology.org/gene/53811/haematological-explorer/css/lib/dataTables.bootstrap.min.css