AMOTL2 (angiomotin like 2)

2014-04-01  

Identity

HGNC
AMOTL2
LOCATION
3q22.2
LOCUSID
51421
ALIAS
LCCP
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 51421
MIM: 614658
HGNC: 17812
Ensembl: ENSG00000114019

Variants:

dbSNP: 51421
ClinVar: 51421
TCGA: ENSG00000114019
COSMIC: AMOTL2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000114019ENST00000249883Q9Y2J4
ENSG00000114019ENST00000422605Q9Y2J4
ENSG00000114019ENST00000502491D6RFG0
ENSG00000114019ENST00000504234D6RF61
ENSG00000114019ENST00000505596D6RJA4
ENSG00000114019ENST00000506107D6RBK2
ENSG00000114019ENST00000510560D6RCL7
ENSG00000114019ENST00000513145Q9Y2J4
ENSG00000114019ENST00000514516Q9Y2J4
ENSG00000114019ENST00000515172D6RIC7

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Tight junctionKEGGko04530
Tight junctionKEGGhsa04530
Signal TransductionREACTOMER-HSA-162582
Signaling by HippoREACTOMER-HSA-2028269

References

Pubmed IDYearTitleCitations
341653502022AmotL2, IQGAP1, and FKBP51 Scaffold Proteins in Glioblastoma Stem Cell Niches.6
341653502022AmotL2, IQGAP1, and FKBP51 Scaffold Proteins in Glioblastoma Stem Cell Niches.6
329505692021AMOTL2 inhibits JUN Thr239 dephosphorylation by binding PPP2R2A to suppress the proliferation in non-small cell lung cancer cells.10
340363992021AMOTL2‑knockdown promotes the proliferation, migration and invasion of glioma by regulating β‑catenin nuclear localization.3
344047332021AMOTL2 mono-ubiquitination by WWP1 promotes contact inhibition by facilitating LATS activation.1
329505692021AMOTL2 inhibits JUN Thr239 dephosphorylation by binding PPP2R2A to suppress the proliferation in non-small cell lung cancer cells.10
340363992021AMOTL2‑knockdown promotes the proliferation, migration and invasion of glioma by regulating β‑catenin nuclear localization.3
344047332021AMOTL2 mono-ubiquitination by WWP1 promotes contact inhibition by facilitating LATS activation.1
307944672019IQGAP1, AmotL2, and FKBP51 Scaffoldins in the Glioblastoma Microenvironment.6
307944672019IQGAP1, AmotL2, and FKBP51 Scaffoldins in the Glioblastoma Microenvironment.6
283684152017Angiomotin-like 2 interacts with and negatively regulates AKT.7
283684152017Angiomotin-like 2 interacts with and negatively regulates AKT.7
265985512016Role of Angiomotin-like 2 mono-ubiquitination on YAP inhibition.34
265985512016Role of Angiomotin-like 2 mono-ubiquitination on YAP inhibition.34
259981282015Phosphorylation of the Hippo Pathway Component AMOTL2 by the mTORC2 Kinase Promotes YAP Signaling, Resulting in Enhanced Glioblastoma Growth and Invasiveness.56

Citation

Dessen P

AMOTL2 (angiomotin like 2)

Atlas Genet Cytogenet Oncol Haematol. 2014-04-01

Online version: http://atlasgeneticsoncology.org/gene/53853/case-report-explorer/